In This Section

Ilker Sariyer, DVM, PhD

Assistant Professor, Neuroscience
Assistant Professor, Neurovirology

Ilker Sariyer
Contact Information

Contact Information

Phone

215-707-6337

Email

ilker.sariyer0001@temple.edu
About Me

Research Interests

My research interests lie in understanding the molecular mechanism of JC virus reactivation in immunocompromised individuals, identifying novel biomarkers for the early detection of the viral reactivation, and developing therapeutic interventions for the treatment of progressive multifocal leucoencephalopathy (PML), a fetal demyelinating disease of the brain caused by JC virus.

Research Summary:

Patients undergoing immune modulatory therapies for the treatment of autoimmune diseases such as multiple sclerosis, and individuals with an impaired-immune system, most notably AIDS patients, are in the high risk group of developing progressive multifocal leukoencephalopath (PML), a fatal demyelinating disease of the white matter caused by human neurotropic polyomavirus, JC virus. We employ multidisciplinary strategies to determine molecular mechanism of JC virus reactivation during the latent period of viral infection. JC virus replicates almost exclusively in glial cells, and its promoter sequence, which has tissue-specific characteristics, tightly modulates expression of viral genome in appropriate cell types and immunoconditions through communication with cellular factors. We identified the alternative splicing factor, SF2/ASF, as a potential regulator of JCV as its overexpression in glial cells strongly suppresses viral gene expression and replication. Our studies have demonstrated that SF2/ASF expression in glial cells is tightly controlled by immune mediators secreted by PBMCs suggesting a novel neuroimmune signaling between immune cells and glial cells that controls the gene expression and replication of the virus. In addition, a major effort in our laboratory is focused on biomarker potential of agnoprotein, a small regulatory protein of JC virus, for the early diagnosis and the prognosis of the PML.

Education, Training & Credentials

Educational Background

  • PhD, Biomedical Sciences, Temple University School of Medicine, Philadelphia, PA, 2011
     
  • DVM, Selcuk University, School of Veterinary Medicine, Konya, Turkey, 2000
Publications

PubMed Publications

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