Neuropathology and Microscopy

We offer histological and immunohistochemical services for the evaluation of human autopsy and biopsy clinical samples, tissues harvested from experimental animal models, and cell cultures. More specifically, this core performs neuropathological evaluation of tissues from animal models and patients with neurological disorders including AIDS, PML, CNS neoplasia, and other neurodegenerative diseases, including peripheral neuropathies. Further, this core provides training in Laser Capture Microdissection (LCM) accessioning of tissue samples and nucleic acid extraction for downstream molecular biological applications, immunohistochemical labeling, photodocumentation, and quantitative analysis of neuronal density and expression of cellular and viral proteins using image analysis systems and methods. Through its microscope facilities, this core assists in training and use of the image capture and analysis techniques. In service hands-on training or seminars on core techniques are held from time to time. Please visit the CNAC website for upcoming sessions.

To schedule a neuropathology consultation, please email cnac@temple.edu. Consultations are available by appointment each week.

For assistance with quantitative image analysis , contact mbarbe@temple.edu.