Microbiome Research

Microbiome and Human Disease Initiative

Symbiotic relationships between microbes (microbiota) and the mammalian host are essential to many key aspects of life.  Conversely, defects in regulatory circuits of host immune pathways or alterations of the microbiome (via infections, diet or lifestyle) can disturb this homeostasis and promote disease. Increasing evidence indicates a key role for microbiota in complex human diseases including autoimmune diseases, cancer, cardiovascular diseases, metabolic diseases and neurodegenerative disorders.

The Center for Microbiology and Immunology has a long-standing interest in microbial lifestyles, mechanisms of infections and inflammation. Our Microbiome and Human Disease Program assists with the design and implementation of research projects that involve the microbiome.  One of the resources employed in this work is our gnotobiotic (Germ-free) mouse facility, managed by Dr. Çağla Tükel.  As it expands, this resource can be made available to researchers throughout the Katz School of Medicine through collaborations and to support grant applications as this new field of research gains momentum in the medical field. 

Please contact Dr. Çağla Tükel (ctukel@temple.edu) or Vincent Tam (vincent.tam@temple.edu) for more information.