Dr. Tomasz Skorski
Postdoctoral positions supported by NIH/NCI grants are immediately available in the laboratory of Dr. Tomasz Skorski, the Director of Fels Cancer Institute for Personalized Medicine at Temple University School of Medicine, Philadelphia. The research is focused on: (1) determination the mechanistic aspects of how mutations driving leukemias modulate DNA damage response, (2) identification of mutation patterns in leukemias, which determine the sensitivity of malignant cells to specific DNA repair inhibitors, and (3) testing new drugs targeting DNA damage response in single cells/clones. Our overall goal is to develop biomarkers that predict tumor response to novel DNA repair inhibitors combined with standard DNA damaging agents and to understand molecular mechanisms. Research involves molecular biology of DNA repair, testing novel drugs, mouse models of cancer, bioinformatics, and extensive mammalian tissue culture. Candidates must be enthusiastic to commit necessary effort required to develop a successful and highly productive research career. Candidates must be residing in the U.S.
Candidates interested in the position should send curriculum vitae, a brief description of research experience, and names of three references to Dr. Tomasz Skorski (Email: tskorski@temple.edu).
Dr. Sergey Karakashev
Postdoctoral positions are available in the laboratory of Dr. Sergey Karakashev. The Karakashev lab investigates the role of epigenetic regulation in ovarian cancer progression with the emphasis on the development of novel therapeutic approaches.
Ongoing research projects:
1. To study the role of epigenetic factor CARM1 in ovarian cancer. And to develop novel therapeutic approaches by targeting CARM1-expressing ovarian cancers with HSP70 inhibitors.
2. To investigate the role of epigenetic factor KDM5A in regulation of immune surveillance in ovarian cancer.
3. To identify novel epigenetic factors regulating antitumor-immune response that could be targeted by epigenetic therapies.
The Karakashev lab is NIH/NCI funded and works in collaboration with several ovarian cancer groups. For more details on research and a list of publications visit: https://pubmed.ncbi.nlm.nih.gov/?term=sergey+karakashev
Candidates should have a PhD (or equivalent) degree or be close to obtaining their doctoral degree and must have at least one first author publication. Required research skills include standard molecular and cellular biology techniques.
Applicants should send their CV via email to Dr. Sergey Karakashev. A CV should include a list of publications, manuscripts in preparation, and technical skills; names and contact information for at least 3 references.
Email: Sergey.Karakashev@temple.edu
Dr. Jayashri Ghosh
The Ghosh laboratory at the Fels Cancer Institute for Personalized Medicine, Temple University is looking for a postdoctoral fellow. The research in the laboratory is focused on investigating epigenetic changes involved in colorectal cancer (CRC) and assisted reproductive technology (ART) through epigenome-wide (DNA methylation) studies. In CRC, the major focus is on Disparity research as CRC incidence and mortality rates are disproportionately higher in Black/African American population.
The ideal candidate will be highly motivated with experience in analyzing large datasets in addition to standard molecular biology techniques. The candidate should have the ability to work independently as well as in a team. Considerable opportunities will be available for professional development.
Required applicant qualifications:
1. A PhD or equivalent degree.
2. Ability to perform molecular biology techniques
3. Experience with data analysis. Knowledge of programming languages like Python or R is a plus.
TO APPLY
Email a CV, cover letter that states research interest(s) and goals, and the name of at least three references to jayashri.ghosh@temple.edu. Qualified candidates will then be invited for a preliminary zoom interview.