Postdoctoral Opportunities at Fels Cancer Institute for Personalized Medicine
Dr. Jonathan Soboloff
Fels Institute (Temple University, Philadelphia, PA) has several openings for a postdoctoral position in Cancer related fields. PIs with openings include:
- Dr. Jonathan Soboloff (Modulation of Ca2+ signaling by STIM1)
I am interested in recruiting a new postdoctoral fellow to study numerous aspects of STIM-dependent Ca2+ signaling. The ideal candidate will have a recent PhD, at least 1 first author publication in a mid- to high-impact journal. Our interests include fundamental mechanisms regulating the generation of Ca2+ signals and their relevance to multiple aspects of immunology, cancer and bone physiology. However, as this lab has just received new funding to investigate T cell activation, the new lab member would be expected to work primarily in this area. Research techniques used in the lab include advanced microscopy approaches, Western analysis, ChIP, qPCR and general molecular biology.
The position is fulltime, with the expectation that the fellow will be independently motivated. As a postdoctoral fellow, the primary duty will be to complete scientific experiments towards the preparation of published works, although I will also support career development as appropriate and needed. The ideal candidate will keep up with relevant literature, contribute to scientific writing and present our research at international conferences with my full support.
Finally, as a senior lab member, I anticipate that the fellow will contribute to the training of junior lab members. When significant, these contributions will be recognized with authorship on publications.
US citizens/green card holders will have opportunities for external funding and will receive special consideration.
Please submit application electronically with curriculum vitae, a cover letter, and the names/phone numbers/emails of three people who can provide letters of reference to: Dr. Jonathan Soboloff, Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA. Email: firstname.lastname@example.org.
Dr. Tomasz Skorski
Postdoctoral positions supported by NIH/NCI grants are immediately available in the laboratory of Dr. Tomasz Skorski, the Director of Fels Cancer Institute for Personalized Medicine at Temple University School of Medicine, Philadelphia. The research is focused on: (1) determination the mechanistic aspects of how mutations driving leukemias modulate DNA damage response, (2) identification of mutation patterns in leukemias, which determine the sensitivity of malignant cells to specific DNA repair inhibitors, and (3) testing new drugs targeting DNA damage response in single cells/clones. Our overall goal is to develop biomarkers that predict tumor response to novel DNA repair inhibitors combined with standard DNA damaging agents and to understand molecular mechanisms. Research involves molecular biology of DNA repair, testing novel drugs, mouse models of cancer, bioinformatics, and extensive mammalian tissue culture. Candidates must be enthusiastic to commit necessary effort required to develop a successful and highly productive research career. Candidates must be residing in the U.S.
Candidates interested in the position should send curriculum vitae, a brief description of research experience, and names of three references to Dr. Tomasz Skorski (Email: email@example.com).
Dr. Christian Hurtz
Postdoctoral positions are available in the laboratory of Dr. Christian Hurtz. The Hurtz lab is NIH/NCI funded and conducts basic and translational research with a focus on identifying novel treatment strategies for patients with acute lymphoblastic leukemia (ALL).
The available postdoctoral research projects focus on:
1) Elucidate oncogene independent signaling activation and determine alternative treatment strategies for patients with high-risk Philadelphia chromosome-like ALL.
2) Validate if inhibition of STAT5 signaling results in V(D)J mediated DNA-damage and determine the importance of DNA repair mechanisms to induce drug resistance.
3) Determine if forced pharmacologic hyperactivation of B cell receptor signaling pathways results in negative selection of malignant cells and validate if signaling hyperactivation is a feasible therapy option for KMT2A-R ALL patients.
Highly motivated applicants with a PhD degree in cancer biology, immunology, molecular biology, or a related area are encouraged to apply. Practical experience with molecular and cellular biology techniques and animal models is required as well as at least 1 first author publication. Preference will be given to recently graduated candidates with a strong career motivation who resides in the US. Competitive stipend and a generous benefits package commensurate with experience will be provided.
To learn more about our research please visit:
Please submit application electronically with curriculum vitae, a cover letter with a brief description of research experience, and the names/phone number/emails of three references to:
Dr. Sergey Karakashev
Postdoctoral positions are available in the laboratory of Dr. Sergey Karakashev. The Karakashev lab investigates the role of epigenetic regulation in ovarian cancer progression with the emphasis on the development of novel therapeutic approaches.
Ongoing research projects:
1. To study the role of epigenetic factor CARM1 in ovarian cancer. And to develop novel therapeutic approaches by targeting CARM1-expressing ovarian cancers with HSP70 inhibitors.
2. To investigate the role of epigenetic factor KDM5A in regulation of immune surveillance in ovarian cancer.
3. To identify novel epigenetic factors regulating antitumor-immune response that could be targeted by epigenetic therapies.
The Karakashev lab is NIH/NCI funded and works in collaboration with several ovarian cancer groups. For more details on research and a list of publications visit: https://pubmed.ncbi.nlm.nih.gov/?term=sergey+karakashev
Candidates should have a PhD (or equivalent) degree or be close to obtaining their doctoral degree and must have at least one first author publication. Required research skills include standard molecular and cellular biology techniques.
Applicants should send their CV via email to Dr. Sergey Karakashev. A CV should include a list of publications, manuscripts in preparation, and technical skills; names and contact information for at least 3 references.
Dr. Swayam Prabha
The lab has an opening for a postdoctoral research associate in the areas of cell-based targeting of chemotherapeutics to solid tumors. The ideal candidate will join a basic and translational research program focused on understanding the mechanisms underlying immune cell activation and immunosuppression within the tumor microenvironment. We work, in particular, with mesenchymal stem cells that are engineered to carry immunomodulators. Our work is based on the use of cell engineering and antibody technologies to investigate targeted therapy against various solid tumors.
The ideal candidate will have a PhD or MD/PhD in cancer biology, cell biology, immunology, molecular biology or a related discipline with a background in immunology and a passion for science and desire to impact cancer. A highly organized and self-directed individual with strong interpersonal skills and the ability to work in a dynamic environment is desired. Advanced molecular biology skills and familiarity with cancer pathogenesis, cell-based therapy and knowledge of molecular/genetic concepts, experimental methods, and data analysis, and ability to maximize resources for troubleshooting pertaining to research activities are essential. Experience using mouse models, a willingness to do animal work and being comfortable with handling of human blood and other tissues is desired.
Dr. Nora Engel
Postdoctoral Position to investigate sex biases in cancer susceptibility and progression, using cell lines and mouse models. The Fels Institute for Cancer Research is a prestigious research institute affiliated with the Temple University School of Medicine, with a strong focus in epigenetics, signaling and cancer. Applicants must have a Ph.D., a background in epigenetics, and proficiency in a range of cell/developmental biology, molecular, immunological, and genomic techniques, including experience in tissue culture, flow cytometry, DNA methylation analysis, and chromatin immunoprecipitation. Experience with mice is required. Excellent oral and written English language skills are essential. Basic bioinformatic skills are a plus. Candidate should be highly motivated, creative, with strong work ethic and ability to work independently as well as in collaborative research efforts. Applicants must have at least 1 first author publication from his/her PhD training. Please submit application electronically with curriculum vitae, a cover letter with statement of research interests and how you think you can contribute to the lab, and the names/phone numbers/emails of three people who can provide letters of reference to: Dr. Nora Engel, Fels Institute of Cancer Research and Molecular Biology, Temple School of Medicine, Philadelphia, PA. email: firstname.lastname@example.org