In This Section

Dale Haines, PhD

Associate Professor, Medical Genetics and Molecular Biochemistry
Associate Professor, Fels Institute for Cancer Research

Dale Haines
Contact Information

Contact Information

Phone

215-707-5765

Fax

215-707-2805

Email

dhaines@temple.edu
About Me

Research Interests

ERGIC-53 is a ER-localized protein that functions in moving client proteins from the ER to a poorly understood sub-cellular structure called the ERGIC. The ERGIC is currently thought to be a sorting station that routes proteins for delivery to the Golgi and retrograde transport of ERGIC-53 back to the ER. In addition, it has been hypothesized to function in protein folding and quality control of secretory proteins that have departed the ER. The current focus of the Haines’ lab is to define using LC-MS/MS based approaches the content of ERGIC-53 containing vesicles and determine how newly identified ERGIC-53 interacting proteins comprised of p97-UBXD1 and Rab3GAP1/2 complexes control the trafficking and function of these vesicles in human cells. As some recently identify contents of ERGIC-53 vesicles have been shown to function in autophagy and tumor cell metastasis, there is a particular in defining the role of ERGIC-53 and interacting proteins in these processes.

Education, Training & Credentials

Educational Background

  • Visiting Scholar, Proteomics, California Institute of Technology, Summers 2010-2012
     
  • Postdoctoral fellowship, Molecular Oncology, University of Pennsylvania School of Medicine (laboratory of Donna George), 1994
     
  • PhD, Molecular Biology, Hahnemann University, 1992
     
  • BA, Biology, University of Delaware, 1988
Publications

PubMed Publications

View PubMed Publications