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The program completes an individualized holistic review of each completed application including, but not limited to, the candidate's academic history, the college attended, standardized test scores, CASPer results, recommendations, extracurricular activities, work experience, medically related experience, and community service activities to select candidates for interview. While not required, many students have participated in research activities.

An interview (by invitation only), serves as a candidate’s interview for conditional acceptance to the MD program and is required to be considered for admission into the LKSOM ACMS Postbaccalaureate program. All offers of admission to the ACMS program include a conditional acceptance to the LKSOM MD program. The requirements that ACMS students must meet to gain full acceptance to the MD program are detailed in the offer of acceptance to the Postbaccalaureate program.