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In new work, Lewis Katz School of Medicine at Temple University researchers show how fibroblast activation and myofibroblast formation occurs, providing clues as to how to target fibrosis, which impacts several chronic diseases.

Results from two Phase III, international clinical trials named GALATHEA and TERRANOVA showed that the asthma drug benralizumab failed to decrease annual COPD exacerbation rates for patients with moderate to very severe COPD, a history of frequent moderate and/or severe exacerbations, and eosinophilic inflammation.

Circular RNAs, like other noncoding RNAs, were thought to be nonfunctional, but recent evidence suggests otherwise. Circular RNAs may in fact act like sponges to “soak up,” or bind, other molecules, including microRNAs and proteins, and now, new work by researchers at the Lewis Katz School of Medicine at Temple University and colleagues supports this idea.