High impact publications from the Center.

Lipid-mediated hydrophobic gating in the BK potassium channel

Lipid-mediated hydrophobic gating in the BK potassium channel
Coronel L, Di Muccio G, Rothberg BS, Giacomello A, Carnevale V. Nature Commun. 2025 Aug 9;16(1):7354. doi: 10.1038/s41467-025-61638-9. PMID: 40783487

Salivary gland-mediated nitrate recirculation as a modulator for cardiovascular diseases

Salivary gland-mediated nitrate recirculation as a modulator for cardiovascular diseases
Pang B, Qi X, Zhang H*. Salivary gland-mediated nitrate recirculation as a modulator for cardiovascular diseases. Biomolecules. 2025 Mar 19;15(3):439.  doi: 10.3390/biom15030439. 

SARS-CoV-2 neutralizing antibody determination after vaccination using spectrophotometric measurement of lateral flow immunochromatography

SARS-CoV-2 neutralizing antibody determination after vaccination using spectrophotometric measurement of lateral flow immunochromatography
Ma J, Kaniper S, Vabishchevich Y, Nyantakyi N, Lynch D, Chun F, Dai HL, Gerhard GS. Sci Rep. 2025 Feb 24;15(1):6577. doi: 10.1038/s41598-025-90730-9. PMID: 39994387; PMCID: PMC11850742. 

Genome Assembly of Arctica islandica, the Longest-Lived Non-Colonial Animal Species

Genome Assembly of Arctica islandica, the Longest-Lived Non-Colonial Animal Species
Gerhard GS, Allard JB, Kaniper S, Lynch D, Lee H, Kumar S.  Animals (Basel). 2025 Feb 27;15(5):690. doi: 10.3390/ani15050690. PMID: 40075973; PMCID: PMC11899663. 

Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice

Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice
Wurtzel, J, Gray, B. D, Pak, K.Y., Zhao, X., Ma, P., McKenzie, S.E., Tanujaya, M., Rizzo, V., Carpio-Cano, F.D., Rao, A.K., Chong, P.L.-G., and Goldfinger, L. (2025)  Journal of Thrombosis and Haemostasis, 23, 108-122. S1538-7836(24)00613-5. doi: 10.1016/j.jtha.2024.10.007. 

Archaea Membranes in Response to Extreme Acidic Environments

Archaea Membranes in Response to Extreme Acidic Environments
Chong, P.L.-G. (2024)   Frontiers in Biophysics, 1, 1338019. doi: 10.3389/frbis.2023.1338019. 

A novel Nedd4l-Txnip-Chop Axis in the Pathogenesis of Nonalcoholic Steatohepatitis

A novel Nedd4l-Txnip-Chop Axis in the Pathogenesis of Nonalcoholic Steatohepatitis
Guo, Q., Xin, M., Lu, Q., Feng. D., Peng, L.F., Whelan, K. A., Hu, W., Wu, S., Yang, X., Wang, H., Rothberg, B.S., Gamero, A.M., Gerhard, G.S., Gao, B. and Yang, L. Y.  Theranostics, 13:2210-2225, 2023. PMCID: PMC10157740

Protein expression/secretion boost by a novel unique 21-mer cis-regulatory motif (Exin21) via mRNA stabilization

Protein expression/secretion boost by a novel unique 21-mer cis-regulatory motif (Exin21) via mRNA stabilization
Zhu Y, Saribas AS, Liu J, Lin Y, Bodnar B, Zhao R, Guo Q, Ting J, Wei Z, Ellis A, Li F, Wang X, Yang X, Wang H, Ho WZ, Yang L, Hu W. - PubMed  Mol Ther. 2023 Apr 5;31(4):1136-1158. doi: 10.1016/j.ymthe.2023.02.012. Epub 2023 Feb 14. PubMed PMID: 36793212; PubMed Central PMCID: PMC9927791.

Identification of Gm15441, a Txnip antisense lncRNA, as a critical regulator in liver metabolic homeostasis

Identification of Gm15441, a Txnip antisense lncRNA, as a critical regulator in liver metabolic homeostasis
Xin M, Guo Q, Lu Q, Lu J, Wang PS, Dong Y, Li T, Chen Y, Gerhard GS, Yang XF, Autieri M, Yang L. - PubMed  Cell Biosci. 2021 Dec 14;11(1):208. doi: 10.1186/s13578-021-00722-1. PubMed PMID: 34906243; PubMed Central PMCID: PMC8670210.

State-dependent inhibition of BK channels by the opioid agonist loperamide

State-dependent inhibition of BK channels by the opioid agonist loperamide
Vouga AG, Rockman ME, Yan J, Jacobson MA, Rothberg BS.  J Gen Physiol. 2021 Sep 6;153(9):e202012834. doi: 10.1085/jgp.202012834. PMID: 34357374 

LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling

LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling
Lu Q, Guo Q, Xin M, Lim C, Gamero AM, Gerhard GS, Yang L. Noncoding RNA. 2021 Aug 28;7(3). doi: 10.3390/ncrna7030052. PubMed PMID: 34564314; PubMed Central PMCID: PMC8482154.

A map of cis-regulatory elements and 3D genome structures in zebrafish

A map of cis-regulatory elements and 3D genome structures in zebrafish
Yang H, Luan Y, Liu T, Lee HJ, Fang L, Wang Y, Wang X, Zhang B, Jin Q, Ang KC, Xing X, Wang J, Xu J, Song F, Sriranga I, Khunsriraksakul C, Salameh T, Li D, Choudhary MNK, Topczewski J, Wang K, Gerhard GS, Hardison RC, Wang T, Cheng KC, Yue F.  Nature. 2020 Dec;588(7837):337-343. doi: 10.1038/s41586-020-2962-9. Epub 2020 Nov 25. PMID: 33239788; PMCID: PMC8183574.

Molecular mechanism of BK channel activation by the smooth muscle relaxant NS11021

Molecular mechanism of BK channel activation by the smooth muscle relaxant NS11021
Rockman ME, Vouga AG, Rothberg BS.  J Gen Physiol. 2020 Jun 1;152(6):e201912506. doi: 10.1085/jgp.201912506. PMID: 32221543