Mechanism for local attenuation of DNA replication at double-strand breaks.

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ADH5/ALDH2 dehydrogenases and DNA polymerase theta protect normal and malignant hematopoietic cells from formaldehyde challenge: therapeutic implications.

Atkins J, Kukuyan AM, Toma M, Drzewiecka M, Vekariya U, Karami A, Nieborowska-Skorska M, Nejati R, Hadzijusufovic E, Valent P, Stoklosa T, Sliwinski T, Wasik M, Skorski T. Leukemia. 2025;39(9):2152-62. Epub 2025/07/11. doi: 10.1038/s41375-025-02687-3. PubMed PMID: 40640557; PMCID: PMC12380611.

PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer.

Torres-Ayuso P, Katerji M, Mehlich D, Lookingbill SA, Sabbasani VR, Liou H, Casillas AL, Chauhan SS, Serwa R, Rubin MR, Marusiak AA, Swenson RE, Warfel NA, Brognard J. Cell Chem Biol. 2024;31(2):326-37 e11. Epub 2023/11/29. doi: 10.1016/j.chembiol.2023.10.023. PubMed PMID: 38016478; PMCID: PMC10922308.

PARG is essential for Poltheta-mediated DNA end-joining by removing repressive poly-ADP-ribose marks.

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FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55alpha/PP2A through helical motifs.

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Autophagy Contributes to Homeostasis in Esophageal Epithelium Where High Autophagic Vesicle Level Marks Basal Cells With Limited Proliferation and Enhanced Self-Renewal Potential.

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ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer.

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Interferon-gamma signaling promotes melanoma progression and metastasis.

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Local production of reactive oxygen species drives vincristine-induced axon degeneration.

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Diclofenac exhibits cytotoxic activity associated with metabolic alterations and p53 induction in ESCC cell lines and decreases ESCC tumor burden in vivo.

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Mass Cytometry as a Tool for Investigating Senescence in Multiple Model Systems.

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HIV-1 gp120 protein promotes HAND through the calcineurin pathway activation.

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Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination-Deficient Leukemia Cells.

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Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells. 

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Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer.

Deneka AY, Baca Y, Serebriiskii IG, Nicolas E, Parker MI, Nguyen TT, Xiu J, Korn WM, Demeure MJ, Wise-Draper T, Sukari A, Burtness B, Golemis EA. Clin Cancer Res. 2022;28(9):1925-37. Epub 2022/05/03. doi: 10.1158/1078-0432.CCR-21-4316. PubMed PMID: 35491653; PMCID: PMC9186806.

Epigenome-Wide Study Identifies Epigenetic Outliers in Normal Mucosa of Patients with Colorectal Cancer.

Ghosh J, Schultz BM, Chan J, Wultsch C, Singh R, Shureiqi I, Chow S, Doymaz A, Varriano S, Driscoll M, Muse J, Kleiman FE, Krampis K, Issa JJ, Sapienza C. Cancer Prev Res (Phila). 2022;15(11):755-66. Epub 2022/10/12. doi: 10.1158/1940-6207.CAPR-22-0258. PubMed PMID: 36219239; PMCID: PMC9623234.

Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium.

Kabir MF, Karami AL, Cruz-Acuna R, Klochkova A, Saxena R, Mu A, Murray MG, Cruz J, Fuller AD, Clevenger MH, Chitrala KN, Tan Y, Keith K, Madzo J, Huang H, Jelinek J, Karakasheva T, Hamilton KE, Muir AB, Tetreault MP, Whelan KA. Nat Commun. 2022;13(1):2167. Epub 2022/04/22. doi: 10.1038/s41467-022-29747-x. PubMed PMID: 35443762; PMCID: PMC9021266.

Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers.

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TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin. 

Torres-Ayuso P, An E, Nyswaner KM, Bensen RC, Ritt DA, Specht SI, Das S, Andresson T, Cachau RE, Liang RJ, Ries AL, Robinson CM, Difilippantonio S, Gouker B, Bassel L, Karim BO, Miller CJ, Turk BE, Morrison DK, Brognard J. Cancer Discov. 2021;11(6):1411-23. Epub 2021/01/27. doi: 10.1158/2159-8290.CD-20-0797. PubMed PMID: 33495197; PMCID: PMC8178189.

EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition. 

Karakashev S, Fukumoto T, Zhao B, Lin J, Wu S, Fatkhutdinov N, Park PH, Semenova G, Jean S, Cadungog MG, Borowsky ME, Kossenkov AV, Liu Q, Zhang R. Cancer Cell. 2020;37(2):157-67 e6. Epub 2020/02/01. doi: 10.1016/j.ccell.2019.12.015. PubMed PMID: 32004442; PMCID: PMC7155421.