Domenico Praticò, MD
Scott Richards North Star Charitable Foundation Chair for Alzheimer’s Research
Professor and Director, Alzheimer's Center at Temple
Professor, Microbiology and Immunology
- Contact Information
- About Me
Dr. Praticò’s research area is clinical pharmacology with a special focus on the cellular and molecular aspects of cell oxidative biology and a particular interest in small molecules such as bioactive oxidized lipids.
This area is very broad and extends to multiple disciplines including aging, cardiovascular diseases as well as neurodegeneration. Our work in the biology of oxidized bioactive lipids has significantly contributed to the current understanding of their importance as biomarkers, mediators of cellular and molecular events involved in the pathogenesis of several clinical conditions, and therapeutic targets for preventing and treating human diseases. In our lab we employ cellular and animal models of human diseases, and in this context particular emphasis is given to the translation of any observation made in these systems into a better understanding of human physiology and pathology. Our group is committed to foster collaborative scientific research of the highest quality, and at the same time to provide outstanding teaching and mentoring for young scientists.
- Education, Training & Credentials
- Fellowship, Hemocoagulation, Hospital of the University of Rome "La Sapienza," 1991; Cardiovascular Science, University of Dublin, Ireland, 1994
- Residency, Hospital of the University of Rome "La Sapienza," 1991
- Internship, Hospital of the University of Rome "La Sapienza"
- MD, University of Rome "La Sapienza," Rome, Italy, 1986
- Internal Medicine, University of Rome "La Sapienza"
- Society for Neuroscience
- Italian Research Council
- American Federation for Medical Research
- American Heart Association
- New York Academy of Science
- International Academy of Cardiology
Praticò, D. Causes and consequences of oxidative stress in neurodegenerative diseases. In: Genotype, Proteotype and Phenotype relationships in neurodegenerative diseases. Eds. J. Cummings and Y. Christen. Springer Publisher; pp.37-44 (2005) (chapter)
Cyrus, T., Praticò, D. Antioxidants and chronic cardiovascular diseases: animal studies. In: Antioxidants and Cardiovascular Disease. 2nd Edition. Eds. M.G. Bourassa, J-C Tardif. Springer Publishers; pp. 227-253 (2006) (chapter)
Cyrus, T., Praticò, D. Vitamin E and Atherosclerosis. In: The encyclopedia of Vitamin E. Eds.V.R. Preedy and R.R. Watson. CABI Publishing, Wallingford, UK; pp. 623-632 (2006) (chapter)
Cyrus, T., Praticò, D. Vitamin E and Atherosclerosis: Animal and Human trials. In: Vitamin E: New Research. Ed. Matthew H. Braunstein. Nova Science Publishers; pp.177-199 (2006) (chapter)
Praticò, D. Antioxidants and endothelium protection. In: Endothelial dysfunction and vascular disease. Eds. R. De Caterina and P. Libby. Blackwell Futura Publishing; pp. 315-322 (2007) (chapter)
de Leon, M.J., Mosconi, L., Blennow, K., De Santi, S., Zinkowski, R., Mehta, P.D., Praticò, D., Tsui, W., Saint Louis, L.A., Sobanska, L., Brys, M., Li, Y., Rich, K., Rinne, J., Rusinek, H. Imaging and CSF studies in the preclinical diagnosis of Alzheimer’s disease. In: Imaging and the Aging Brain. Eds. DeLeon MJ, Snider DA, and Federoff H. Blackwell Publishing; pp.114-45.2 (2007) (chapter)
Praticò, D., Polidori, M.C., Mecocci, P. Vitamin E, dementia and cognitive function. In: Vitamins and the prevention of human diseases. Eds. Herrmann W., Obeid R. De Gruyter Publishing; pp.503-514 (2010) (chapter).