Scott Richards North Star Foundation and Stop Alzheimer’s Now Chair in Alzheimer’s Research

RESEARCH INTERESTS
The research in my lab focuses on the molecular pathogenesis of cerebrovascular disorders and the cell-death mechanisms underlying neurodegeneration in Alzheimer’s disease (AD), cerebral amyloid angiopathy (CAA), traumatic brain injury (TBI), and post-traumatic stress disorder (PTSD).

We analyze the effects of cellular oxidative and mitochondrial stress, apoptosis, and inflammation and explore pharmacological compounds capable of inhibiting these events. Also, we are actively searching for novel diagnostic biofluid biomarkers for AD, TBI, PTSD.

My interests have recently centered on how different amyloid aggregation species modulate molecular mechanisms and signaling pathways that trigger cell toxicity and cell stress responses in AD and CAA. In particular, we are focusing on mitochondrial dysfunction in cells comprising the neurovascular unit and in neuronal and glial cells.

We are deeply interested in the effects of amyloid variants on endothelial cell death and blood–brain barrier permeability, as well as the contribution of mitochondria, death receptors, and inflammation mediators in these events. By applying biochemical, molecular, and imaging techniques in cultured cells, animal models, and human AD or CAA brain neurovascular cells, we identified the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptors, DR4 and DR5, as targets for amyloid beta oligomers, which are responsible for the initiation of mitochondrial apoptosis in brain vascular cells.

Currently, we are studying the protective effects of carbonic anhydrase inhibitors against mitochondrial failure in amyloid-challenged cells and animal models. Our ongoing studies also explore the interactions between AD, cerebral amyloidosis, and cardiovascular risk, as well as between tau pathology and TBI and their combined effects on mitochondrial dysfunction and neurovascular cell death. Our goals are twofold: to unveil new drug development targets that can protect brain neuronal and vascular cells against neurodegeneration, cerebral hypoperfusion, and hemorrhage, and to discover new biomarkers for these diseases.

EDUCATION, TRAINING & CREDENTIALS

• Postdoctoral Fellowship, Pathology, NYU School of Medicine, New York, NY
• PhD, Pharmacology and Toxicology, University of Florence, Italy
• Research Fellowship, Pharmacology, University of Florence, Italy
• BS, Molecular Biology, University of Florence, Italy

MEMBERSHIPS

• Society for Neuroscience
• International Society to Advance Alzheimer’s Research and Treatment (ISTAART)
• American Heart Association
• Italian Scientists and Scholars in North America Foundation (ISSNAF)
• Vas-Cog Society: The international society of vascular behavioral and cognitive disorders
• Grant Reviewer for The Alzheimer’s Association, Chicago, IL
• Grant Reviewer for The Italian Ministry of Health, the Swedish Research Council, the Medical Research Council (UK), the American Institute of Biological Sciences, the Alzheimer’s Society UK
• Grant Reviewer for the National Institutes of Health (NIH)
• Grant Reviewer for US Department of Defense
• Biomarker Professional Interest Area (PIA) and Biofluid Biomarker Reference Ranges Working Group for the Alzheimer’s Association
• Vascular PIA and working group on White Matter Lesions for the Alzheimer’s Association
• US Department of Defense CDMRP PRARP Study Section

HONORS & AWARDS

• Leon Levy Fellowship in Neuroscience, 2016
• Director of the Biofluid Biomarkers Core of the Cohen Veteran Center, NYULMC Department of Psychiatry, 2015-19
• Blas Frangione Foundation New Investigator Research Grant, 2014
• Scientist Development Grant Award (2013-2017) from the American Heart Association, 2013
• New Investigator Research Grant Award from the Alzheimer’s Association, 2012
• NYU Alzheimer’s Disease Center Pilot Grant, Center of Excellence on Brain Aging, NYU Langone Medical Center, 2010
• 2020: Received the Thome Memorial Foundation Award in Alzheimer’s Disease Drug Discovery Research
• Awarded the PA Cure Alzheimer’s disease Research Award from the PA Department of Health
• Karen Toffler Charitable Trust Original Scholar at Temple University and Director of the Temple Scholarship Program (2020-Present). 
• 2021 Standing Member of the NOMD NIH Study Section
• 2023 Elected Vice-Chair of the Vascular Cognitive disorders Professional Interest Area of the Alzheimer’s Association.
• 2023 Selected Member of the Scientific Program Committee for the Alzheimer’s Association International Conference (AAIC) 2023-2027.
• 2024 Dawn Marks Faculty Award for Teaching, Mentoring and dedication to Graduate Student’s life and community.
• 2024 Co-Chair of the Vascular Contributions to Cognitive Impairment (VCID) Session of the 2025 NIH/NINDS ADRD Summit.
• 2025 Educational Excellence Award in Research Mentoring, Temple University LKSOM.
• 2025 Elected Chair of the Vascular Cognitive disorders Professional Interest Area of the Alzheimer’s Association.
• 2026 Named the Scott Richards North Star Foundation and Stop Alzheimer’s Now Chair in Alzheimer’s Research

PUBLICATIONS

NCBI Bibliography

Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimers and Dementia (N Y). 2019 Apr 9;5:107-117. doi: 10.1016/j.trci.2019.02.001. eCollection 2019. Review. PMID: 31011621

Silvia Fossati, Jaime Ramos Cejudo, Ludovic Debure, Elizabeth Pirraglia, Je Yeong Sone, Yi Li, Jingyun Chen, Tracy Butler, Henrik Zetterberg, Kaj Blennow, Mony J. de Leon. Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease. Alzheimers and Dementia (Amst). 2019 Jun 28;11:483-492. doi: 10.1016/j.dadm.2019.05.001. eCollection 2019 Dec. PMID: 31334328 (Corresponding author)
 
 Parodi-Rullán R, Sone JY, Fossati S. Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease. J Alzheimers Dis. 2019 Jul 8. doi: 10.3233/JAD-190357. [Epub ahead of print] PMID: 31306129
 
 K Dean, R Hammamieh , S Mellon , D Abu-Amara, …, S Fossati (as part of the PTSD System Biology Consortium), … and C Marmar. Multi-omic biomarker identification and validation for diagnosing warzone-related Post-Traumatic Stress Disorder. Mol Psychiatry. 2019 Sep 10. doi: 10.1038/s41380-019-0496-z. [Epub ahead of print] PMID: 31501510
 
Gustavo Provensi, Fabrizio Carta, Alessio Nocentini, Claudiu T. Supuran, Fiorella Casamenti, M. Beatrice Passani, Silvia Fossati. A new kid on the block? Carbonic Anhydrases as a possible new target
in Alzheimer’s Disease. Int J Mol Sci. 2019 Sep 24;20(19). pii: E4724. doi: 10.3390/ijms20194724. Review. PMID: 31554165
 
Patrizia Giannoni, Silvia Fossati, Elena Marcello and Sylvie Claeysen. Editorial: Identification of Multiple Targets in the Fight Against Alzheimer's Disease. Front. Aging Neurosci., 2020 Jun 16;12:169. doi: 10.3389/fnagi.2020.00169. eCollection 2020. PMID: 32612524
 
Kang JI, Mueller SG, Wu GWY, Lin J, Ng P, Yehuda R, Flory JD, Abu-Amara D, Reus VI, Gautam A,… Fossati S (as part of the PTSD System Biology Consortium)…., Hammamieh R, Doyle FJ 3rd, Jett M, Marmar CR, Mellon SH, Wolkowitz OM. Effect of Combat Exposure and Posttraumatic Stress Disorder on Telomere Length and Amygdala Volume. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Jul;5(7):678-687. doi: 10.1016/j.bpsc.2020.03.007. Epub 2020 Mar 31. PMID: 32439402
 
Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, Hawkes CA, Koronyo-Hamaoui M, Hainsworth AH, Holtzman D, Ihara M, Jefferson A, Kalaria RN, Kipps CM, Kanninen KM, Leinonen V, McLaurin J, Miners S, Malm T, Nicoll JAR, Piazza F, Paul G, Rich SM, Saito S, Shih A, Scholtzova H, Snyder H, Snyder P, Thormodsson FR, van Veluw SJ, Weller RO, Werring DJ, Wilcock D, Wilson MR, Zlokovic BV, Verma A. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimers Dement (Amst). 2020 Aug 3;12(1):e12053. doi: 10.1002/dad2.12053. eCollection 2020. PMID: 32775596 Free PMC article.
 
Parodi R., Ghiso J., Cabrera E., Rostagno A. and Fossati S. Alzheimer’s amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis. Aging Cell. 2020 Nov;19(11):e13258. doi: 10.1111/acel.13258. Epub 2020 Nov 6. PMID: 33155752
 
Cantero JL, Atienza M, Ramos-Cejudo J, Fossati S, Wisniewski T, Osorio RS. Plasma tau predicts cerebral vulnerability in aging. Aging (Albany NY). 2020 Nov 4;12(21):21004-21022. doi: 10.18632/aging.104057. Epub 2020 Nov 4. PubMed PMID: 33147571; PubMed Central PMCID: PMC7695405.
 
Canepa E. and Fossati S. Impact of tau on neurovascular pathology in Alzheimer's disease. Frontiers in Neurology 2020;11:573324. doi: 10.3389/fneur.2020.573324. eCollection 2020. Review. PubMed PMID: 33488493; PubMed Central PMCID: PMC7817626.
 
 Jaime Ramos‐Cejudo, Ph.D, Afia Genfi, BS, Duna Abu‐Amara, MPH, Ludovic Debure, BS, Meng Qian, Ph.D, Eugene Laska, Ph.D, Carole Siegel, Ph.D, Nicholas Milton, BSE, Jennifer Newman, Ph.D, Esther Blessing, M.D Ph.D, Meng Li, MA, Amit Etkin, M.D Ph.D, Charles R. Marmar, M.D, Silvia Fossati, Ph.D.
CRF serum levels differentiate PTSD from healthy controls and TBI in military veterans. Psychiatric Research and Clinical Practice 2021. Published Online:1 Jun 2021 https://doi.org/10.1176/appi.prcp.20210017
 
 Wisniewski T, Fossati S. Reader Response: Blood Biomarkers of Traumatic Brain Injury and Cognitive Impairment in Older Veterans. Neurology. 2021 Jul 13;97(2):101. doi: 10.1212/WNL.0000000000012255.
PMID: 34253655 No abstract available.
 
Rebecca M. Parodi-Rullán, Sabzali Javadov and Silvia Fossati. Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Cells 2021, 10(11), 2903; https://doi.org/10.3390/cells10112903
 
Nicole Lemon, Elisa Canepa, Marc A. Ilies and Silvia Fossati. Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimer’s Disease and Stroke. Front. Aging Neurosci., 16 November 2021 | https://doi.org/10.3389/fnagi.2021.772278
 
Sehwan Jang, Xavier R Chapa-Dubocq, Silvia Fossati and Sabzali Javadov. Analysis of mitochondrial calcium retention capacity in cultured cells: permeabilized cells versus isolated mitochondria. Frontiers in Physiology. 2021 Dec 7;12:773839. doi: 10.3389/fphys.2021.773839. PMID: 34950052
 
Jang S, Chapa-Dubocq XR, Parodi-Rullán RM, Fossati S, Javadov S. Beta-Amyloid Instigates Dysfunction of Mitochondria in Cardiac Cells. Cells. 2022 Jan 22;11(3):373. doi: 10.3390/cells11030373. PMID: 35159183
 
Ashley Carey and Silvia Fossati. Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers. Alzheimer’s & Dementia 2022 Nov 19. doi: 10.1002/alz.12871. Online ahead of print. PMID: 36401868 (Award for “Most Downloaded Papers” from Alzheimer’s & Dementia in 2023).
 
 Fossati S. Editorial: Women in aging neuroscience 2021. Front Aging Neurosci. 2023 Jan 26;15:1140899. doi: 10.3389/fnagi.2023.1140899. eCollection 2023. PMID: 36776435
 
 Elia A, Fossati S. Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer's disease. Front Physiol. 2023 Jan 30;14:1060666. doi: 10.3389/fphys.2023.1060666. eCollection 2023. PMID: 36798942
 
 Xu M, Lin Z, Siegel CE, Laska EM, Abu-Amara D, Genfi A, Newman J, Jeffers MK, Blessing EM, Flanagan SR, Fossati S, Etkin A, Marmar CR. Screening for PTSD and TBI in Veterans using Routine Clinical Laboratory Blood Tests. Transl Psychiatry. 2023 Feb 21;13(1):64. doi: 10.1038/s41398-022-02298-x. PMID: 36810280
 
Elisa Canepa, Rebecca Parodi-Rullan, Rafael Vazquez-Torres, Begona Gamallo Lana, Roberto Guzman-Hernandez, Nicole L. Lemon, Federica Angiulli, Ludovic Debure, Marc A. Ilies, Leif Østergaard, Thomas Wisniewski, Eugenio Gutiérrez-Jiménez, Adam C. Mar and Silvia Fossati. FDA-approved carbonic anhydrase inhibitors reduce Amyloid-β pathology and improve cognition by ameliorating cerebrovascular health and glial fitness. Alzheimer’s & Dementia, First published: 26 April 2023 https://doi.org/10.1002/alz.13063
 
Jang S, Chorna N, Rodríguez-Graciani KM, Inyushin M, Fossati S, Javadov S. The Effects of Amyloid-β on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells. J Alzheimers Dis. 2023 Mar 23. doi: 10.3233/JAD-221199. Online ahead of print. PMID: 36970904
 
Kelly L., … , Fossati S.,… Carare R. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. Alzheimers Dement. 2024 Feb;20(2):1421-1435. doi: 10.1002/alz.13512. Epub 2023 Oct 28. PMID: 37897797
 
Amy Anzovino, Elisa Canepa, Micaelly Alves, Nicole L. Lemon, Roxana O. Carare and Silvia Fossati.
Amyloid Beta Oligomers Activate Death Receptors and Mitochondria-Mediated Apoptotic Pathways in Cerebral Vascular Smooth Muscle Cells; Protective Effects of Carbonic Anhydrase Inhibitors. Cells 2023, 12(24), 2840; https://doi.org/10.3390/cells12242840. PMID: 38132159
 
Ashley M Carey, Rebecca Parodi-Rullan, Rafael Vazquez-Torres, Elisa Canepa, Silvia Fossati. Homocysteine potentiates amyloid β-induced cerebral endothelial cell apoptosis, blood brain barrier dysfunction and angiogenic impairment. Aging Cell. 2024 Feb 15:e14106. doi: 10.1111/acel.14106. PMID: 37186121
 
 Roberto Guzman-Hernandez and Silvia Fossati.  Fibrillar tau alters cerebral endothelial cell metabolism, vascular inflammatory activation, and barrier function in vitro and in vivo. Alzheimers Dement. 2025 Mar;21(3):e70077. doi: 10.1002/alz.70077. PMID: 40110691
 
Elia A, Parodi-Rullan R, Vazquez-Torres R, Carey A, Javadov S, Fossati S. Amyloid β instigates cardiac neurotrophic signaling impairment, driving Alzheimer's associated heart disease. bioRxiv [Preprint]. 2025 Jun 4:2023.07.11.548558. doi: 10.1101/2023.07.11.548558. PMID: 37502936 Free PMC article. Preprint.
 
Gutiérrez-Jiménez E, Rasmussen PM, Mikkelsen IK, Kura S, Fruekilde SK, Hansen B, Bordoni L, Carlsen J, Palmfeldt J, Boas DA, Sakadžić S, Vinogradov S, Khatib ME, Ramos-Cejudo J, Wied B, Leduc-Galindo D, Canepa E, Mar AC, Gamallo-Lana B, Fossati S, Østergaard L. “Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis.” Alzheimers Dement. 2025 Mar;21(3):e70023. doi: 10.1002/alz.70023. PMID: 40133235
 
Jasper Carlsen, Silvia Fossati, Leif Østergaard, Eugenio Gutiérrez-Jiménez, Johan Palmfeldt. Cerebral Proteome Adaptations to Amyloid Angiopathy are Prevented by Carbonic Anhydrase Inhibitors. Alzheimers Dement. 2025 Apr;21(4):e70122. doi: 10.1002/alz.70122. PMID: 40285374
 
 Peluzzo AM, St Paul A, Corbett CB, Kelemen SE, Fossati S, Liu X, Autieri MV. IL-19 Is a Novel Lymphangiocrine Factor Inducing Lymphangiogenesis and Lymphatic Junctional Regulation. Arterioscler Thromb Vasc Biol. 2025 Jul;45(7):1244-1265. doi: 10.1161/ATVBAHA.125.322669. Epub 2025 May 15. PMID: 40371466
 
Saaoud F, Ben Issa M, Liu L, Xu K, Lu Y, Shao Y, Han B, Jiang X, Liu X, Gillespie A, Luo JJ, Martinez L, Vazquez-Padron R, Mohsin S, Kosmider B, Wang H, Fossati S, Yang X. Organelle stresses and energetic metabolisms promote endothelial-to-mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer's disease. Front Mol Neurosci. 2025 Aug 22;18:1605012. doi: 10.3389/fnmol.2025.1605012. eCollection 2025. PMID: 40919531

Carey A, Buzhdygan T, Fossati S. Lack of Oxygen and/or Glucose Differentially Potentiates Aβ40e22q- and Aβ42-Induced Cerebral Endothelial Cell Death, Barrier Dysfunction and Angiogenesis Impairment. Cells. 2026 Feb 27;15(5):424. doi: 10.3390/cells15050424. PMID: 41827857 Free PMC article.
 
Elia A, Parodi-Rullan R, Vazquez-Torres R, Carey A, Zhao H, Javadov S, Fossati S. Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease. Adv Sci (Weinh). 2026 Apr;13(20):e11924. doi: 10.1002/advs.202511924. Epub 2026 Feb 10. PMID: 41665021
 
 Lemon NL, Canepa E, Vázquez-Torres R, Parodi-Rullán R, Hirt T, Petersohn LM, Rifat T, Abyaneh MH, Ilies MA, Fossati S. Mitochondrial carbonic anhydrase-VB inhibition rescues brain endothelial stress and memory in Alzheimer's disease models. bioRxiv [Preprint]. 2026 Mar 18:2026.03.16.711716. doi: 10.64898/2026.03.16.711716. PMID: 41890077 Free PMC article. Preprint.

S. Fossati*, E. Rapizzi*, F. Moroni, A. Chiarugi. Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes. Mol Pharmacol. 2004; 66(4):890-8.

 A. Cozzi, G. Cipriani, S. Fossati, G. Faraco, L. Formentini, W. Min, U. Cortes, Z.Q. Wang, F. Moroni, A. Chiarugi. Poly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice. J Cereb Blood Flow Metab. 2006; 26(5):684-95.

S. Fossati , L. Formentini, Z.Q. Wang, F. Moroni and A. Chiarugi. Poly (ADP-ribosyl)ation regulates heat shock factor-1 activity and the heat shock response in murine fibroblasts. Biochem Cell Biol., 2006; 84(5):703-12.

S. Fossati, G. Cipriani, F. Moroni, A. Chiarugi. Neither energy collapse nor transcription underlie in vitro neurotoxicity of poly(ADP-ribose) polymerase hyper-activation. Neurochem Int., 2006, 50(1), 203-10.

M. Porcu, F. Guarna, L. Formentini, G. Faraco, S. Fossati, R. Mencucci, E. Rapizzi, U.Menchini, F. Moroni and A. Chiarugi. Carboxymethyl β-glucan binds to corneal epithelial cells and increases cell adhesion to laminin and resistance to oxidative stress. Cornea, 2007, 26(1), 73-9.

S. Fossati and A. Chiarugi. Relevance of High Mobility Group Protein Box 1 (HMGB1) to neurodegeneration. Int. Rev. Neurobiol, 2007;82:137-48. DOI: 10.1016/S0074-7742(07)82007-1.

A. Aldinucci, G. Gerlini, S. Fossati, G. Cipriani, C. Ballerini, T. Biagioli, N. Pimpinelli, L. Borgognoni, L. Massacesi, F. Moroni and A. Chiarugi. Requirement for PARP-1 activity during human dendritic cell maturation. J. Immunol., 2007 1;179(1):305-12.

S. Fossati*, G. Faraco*, M.E. Bianchi, M. Patrone, M. Pedrazzi, B. Sparatore, F. Moroni and A.Chiarugi. High Mobility Group Box 1 Protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo. J. Neurochem. 2007;103(2):590-603.

Solito R., Corti F., Fossati S., Mezhericher E., Donnini S., Ghiso J., Giachetti A., Rostagno A. and Ziche M. Dutch and Arctic mutant peptides of β amyloid 1-40 differentially affect the FGF-2 pathway in brain endothelium. Exp Cell Research 315, 2009: 385–395.

R. J. S. Viana, A. F. Nunes, R. E. Castro, R.M. Ramalho, J. Meyerson, S. Fossati, J. Ghiso, c, A. Rostagno and C. M. P. Rodrigues. Tauroursodeoxycholic acid prevents E22Q Alzheimer’s Aβ toxicity in human cerebral endothelial cells. Cell Mol Life Sci. 2009; 66(6):1094-104.

Faraco G, Pittelli M, Cavone L, Fossati S, Porcu M, Mascagni P, Fossati G, Moroni F, Chiarugi A. Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo. Neurobiol Dis. 2009; 36(2):269-79.

Fossati S, Cam J, Meyerson J, Mezhericher E, Romero IA, Couraud PO, Weksler BB, Ghiso J, Rostagno A. Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls. FASEB J. 2010; 24(1):229-41.

Hernandez-Guillamon M, Mawhirt S, Fossati S, Blais S, Pares M, Penalba A, Boada M, Couraud PO, Neubert TA, Montaner J, Ghiso J, Rostagno A. Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells. J Biol Chem. 2010; 285(35):27144-58.

Fossati S, Ghiso J, Rostagno A. Molecular analysis of apoptotic pathways induced by amyloid-β variants in cerebral vascular cells. Alzheimer’s & Dementia, 2010; 6: S376-S377.

Rostagno A, Fossati S, Ghiso J. Fibrillogenesis and toxicity of Iowa-Aβ amyloid is primarily driven by the D23 mutation. Alzheimer’s & Dementia, 2010; 6: S242.

Fossati S., Ghiso J., Rostagno A. Insights into caspase-mediated apoptotic pathways induced by amyloid-β in cerebral microvascular endothelial cells. Neurodegenerative Diseases 10, 324-328 (2012). SF Corresponding Author.

Fossati S., Ghiso J & Rostagno A. TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer’s Aβ. Cell Death and Disease. 2012 Jun 14;3:e321. doi: 10.1038/cddis.2012.55

Fossati, S; Ghiso, J; Rostagno, A Amyloid beta oligomers trigger death receptors-mediated apoptosis in cerebral endothelial cells. FASEB journal. 2012:26. ISSN: 0892-6638

Fossati S*, Todd K*, Sotolongo K., Ghiso J, Rostagno A. Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation. Biochem J. 2013 Dec 15;456(3):347-60. doi: 10.1042/BJ20130652.

S Fossati, P Giannoni, M Hernandez-Guillamon, J Montaner, J Ghiso, A. Rostagno. Mitochondria and death receptors: Key targets for amyloid toxicity in the cerebral vasculature. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2014-10 (4), P191.

Todd K.; Fossati S.; Ghiso J.; Rostagno A. Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration. Biochim Biophys Acta. - Molecular Basis of Disease 2014 Sep 28. pii: S0925-4439(14)00291-9. doi: 10.1016/j.bbadis.2014.09.010.

Ghiso, J; Fossati, S; Rostagno, A. Amyloidosis associated with cerebral amyloid angiopathy: Cell signaling pathways elicited in cerebral endothelial cells 2014-04-09; 1387-2877, Journal of Alzheimer's Disease - id: 871452, year: 2014.

Fossati, S; Giannoni, P; Solesio, M; Del, Mar Hernandez M; Ghiso, J; Rostagno, A. Death receptors and mitochondria as crucial targets for drug discovery in cerebral amyloid angiopathy. 2015-04-10; 0039-2499, Stroke - id: 1522242, year: 2015.

S Fossati, P Giannoni, M Solesio, S Cocklin, E Cabrera, J Ghiso, A Rostagno. Methazolamide protects neuronal and glial cells from amyloid toxicity in vitro and in vivo via mitochondria-mediated mechanisms. Alzheimer's & Dementia 2015 11(7):P860-P861 (# 1923902).

J Spiegel, E Pirraglia, Y Li, W Tsui, L Glodzik, R Osorio, L A. Saint Louis, C Randall, T Butler, J Xu, R P Zinkowski, H Zetterberg, J Fortea, S Fossati, T Wisniewski, P Davies, K Blennow, M J de Leon. Greater specificity for CSF P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer’s. J Alzheimers Dis. 2015 Sep 28;49(1):93-100. doi: 10.3233/JAD-150167

S Fossati, P Giannoni, M E. Solesio, S L. Cocklin, E Cabrera, J Ghiso and A Rostagno. The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain. Neurobiol Dis. 2016 Feb;86:29-40. doi: 10.1016/j.nbd.2015.11.006. SF Corresponding Author.

Fossati S. Commentary: The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain. World Biomedical Frontiers ISSN: 2328-0166, March 2016. http://biomedfrontiers.org/alzheimer-2016-3-8

Solesio ME Debure L. Pavlov E. Wisniewski T. Fossati S. Carbonic anhydrase is a crucial target for prevention of mitochondrial pathology in Alzheimer’s models. Alzheimer's & Dementia. July 2016. Volume 12, Issue 7, Supplement, Page P650 DOI: https://doi.org/10.1016/j.jalz.2016.06.1261

M.J. de Leon, Y. Li, N Okamura, W.H. Tsui , L.A. Saint-Louis, L. Glodzik, R.S. Osorio, J. Fortea, T. Butler, E. Pirraglia, S. Fossati, H-J Kim, R. O. Carare, M. Nedergaard, H. Benveniste, and H. Rusinek. CSF clearance in Alzheimer Disease measured with dynamic PET. J Nucl Med. 2017 Mar 16. pii: jnumed.116.187211. doi:10.2967/jnumed.116.187211. PMID: 28302766

Fossati S, Cejudo JR, Debure L, et al. Differential value of plasma tau as a biomarker for Alzheimer's disease and chronic traumatic brain injury. Alzheimers’ and Dementia. 2017 Jul;13(7):4-133. DOI: http://dx.doi.org/10.1016/j.jalz.2017.06.1999.

Mony J. de Leon, Elizabeth Pirraglia, Ricardo S. Osorio, Lidia Glodzik, Les Saint-Louis, Hee-Jin Kim, Juan Fortea, Silvia Fossati, Eugene Laska, Carole Siege, Tracy Butler, Yi Li, Henry Rusinek, Henrik Zetterberg, Kaj Blennow. The nonlinear relationship between cerebrospinal fluid Aβ42 and Tau in preclinical Alzheimer’s disease. PLoS One. 2018 Feb 7;13(2):e0191240. doi: 10.1371/journal.pone.0191240. eCollection 2018.

Jaime Ramos-Cejudo, Thomas Wisniewski, Charles Marmar, Henrik Zetterberg, Kaj Blennow, Mony J. de Leon, Silvia Fossati. Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link. EBioMedicine (Lancet and Cell new Open Access Journal) 2018 Jan 30. pii: S2352-3964(18)30025-2. doi: 10.1016/j.ebiom.2018.01.021.

Solesio María E, Peixoto Pablo Debure Ludovic, Madamba Stephen M, de Leon Mony J, Wisniewski Thomas, Pavlov Evgeny and Fossati Silvia. Carbonic Anhydrase Inhibition Selectively Prevents Amyloid β Neurovascular Mitochondrial Toxicity. Aging Cell. 2018 Jun 5:e12787. doi: 10.1111/acel.12787.

Silvia Fossati, Jaime Ramos Cejudo, Afia Genfi, Duna Abu-Amara, Charles Marmar Discovery of Novel Blood Biomarkers for PTSD and TBI. Biological Psychiatry 2018, Volume 83, Issue 9, Supplement, Pages S134–S135. DOI: https://doi.org/10.1016/j.biopsych.2018.02.352

A Etkin, G A. Fonzo, W Wu, J Huemer, B Patenaude, P E. Vértes, J Richiardi, MS. Goodkind, CJ. Keller, J Ramos Cejudo, YV. Zaiko, KK. Peng, E Shpigel, P Longwell, RT. Toll, A Thompson, S Zack, B Gonzalez, R Edelstein, J Chen, I Akingbade, E Weiss, R Hart, S Mann, K Durkin, S Baete, F Boada, A Genfi, J Autea, J Newman, D J. Oathes, S E. Lindley, D Abu-Amara, B A. Arnow, N Crossley, J Hallmayer, S Fossati, B O. Rothbaum, CR. Marmar, ET. Bullmore, R O’Hara. Connectomics and cognition define a treatment-resistant form of post-traumatic stress disorder. Science Translational Medicine, 2018. In press.

Etkin A, Maron-Katz A, Wu W, Fonzo GA, Huemer J, Vértes PE, Patenaude B, Richiardi J, Goodkind MS, Keller CJ, Ramos-Cejudo J, Zaiko YV, Peng KK, Shpigel E, Longwell P, Toll RT, Thompson A, Zack S, Gonzalez B, Edelstein R, Chen J, Akingbade I, Weiss E, Hart R, Mann S, Durkin K, Baete SH, Boada FE, Genfi A, Autea J, Newman J, Oathes DJ, Lindley SE, Abu-Amara D, Arnow BA, Crossley N, Hallmayer J, Fossati S, Rothbaum BO, Marmar CR, Bullmore ET, O'Hara R. Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder. Sci Transl Med. 2019 Apr 3;11(486). pii: eaal3236. doi: 10.1126/scitranslmed.aal3236. PMID: 30944165