High impact publications from the Center.

Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells

https://pubmed.ncbi.nlm.nih.gov/39908265/
Lin CR, Hayek H, Simborio H, Karim L, Bahmed K, Bolla S, Marchetti N, Criner GJ, Tian Y, Kosmider B., Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells, Aging Dis. 2025 Jan 24. doi: 10.14336/AD.2024.1175. Online ahead of print. PMID: 39908265

HOXA1 Contributes to Bronchial Epithelial Cell Cycle Progression by Regulating p21/CDKN1A

https://pubmed.ncbi.nlm.nih.gov/40076953/
McCluskey E, Velli SK, Kaminski R, Markward T, Leming H, Yu D, and Sajjan U. HOXA1 Contributes to Bronchial Epithelial Cell Cycle Progression by Regulating p21/CDKN1A. Int J Mol Sci 2025; 26 (5), 2332. PMID: 40076953; PMCID: PMC11899960; DOI: 10.3390/ijms26052332

Role of Homeobox A1 in Airway Epithelial Generation from Human Airway Basal Cells

https://pubmed.ncbi.nlm.nih.gov/40214503/
Mohsen T, Chen N, and Sajjan U. Role of Hoemobox A1 in Airway Epithelial Generation from Human Airway Basal Cells. Cells 2025; 14(7), 549;

The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and in silico modeling to identify new therapeutics

https://pubmed.ncbi.nlm.nih.gov/38259971/
Liu, D.; Langston, J.C.; Prabhakarpandian, B.; Kiani, M.F. and Kilpatrick, L.E., The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and in silico modeling to identify new therapeutics. Frontiers in Cellular and Infection Microbiology, 2024 Jan 8;13:1274842. doi: 10.3389/fcimb.2023.1274842. PMID: 38259971

Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity

https://pubmed.ncbi.nlm.nih.gov/38524125/
Yang, Q.; Langston, J.C.; Prosniak, R.; Pettigrew, S; Zhao, H.; Perez, E.; Edelmann, H.; Mansoor, N.; Merali, C.; Merali, S.; Marchetti, N.; Prabhakarpandian, B.; Kiani, M.F. and Kilpatrick, L.E., Distinct functional neutrophil phenotypes in sepsis patients correlates with disease severity. Frontiers in Immunology, 2024 Mar 8;15:1341752. j: 10.3389/fimmu.2024.1341752. eCollection 2024. PMID: 38524125 https://pubmed.ncbi.nlm.nih.gov/38259971/

Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema

https://pmc.ncbi.nlm.nih.gov/articles/PMC11583753/
Simborio H, Hayek H, Kosmider B, Elrod JW, Bolla S, Marchetti N, Criner GJ, Bahmed K. Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema. Cell Commun Signal. 2024 Nov 22;22(1):562. doi: 10.1186/s12964-024-01896-0. PMID: 39578839. https://pmc.ncbi.nlm.nih.gov/articles/PMC11583753/ 

The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis

https://pmc.ncbi.nlm.nih.gov/articles/PMC11478129/
Hayek H, Rehbini O, Kosmider B, Brandt T, Chatila W, Marchetti N, Criner GJ, Bolla S, Kishore R, Bowler RP, Bahmed K. The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2024 Apr;70(4):259-282. doi: 10.1165/rcmb.2023-0232OC. PMID: 38117249. https://pmc.ncbi.nlm.nih.gov/articles/PMC11478129/ 

Quercetin improves epithelial regeneration from airway basal cells of COPD patients

https://pubmed.ncbi.nlm.nih.gov/38468259/
McCluskey ES, Liu N, Pandey A, Marchetti N, Kelsen SG, Sajjan US Quercetin Improves Airway Epithelial Regeneration from Airway Basal Cells of COPD Patients. Respir Res. 2024 Mar 11;25(1):120. PMID: 38468259; doi: 10.1186/s12931-024-02742-0. https://pubmed.ncbi.nlm.nih.gov/38468259/ 

Increased Expression of miR146a Dysregulates TLR2-Induced HBD2 in Airway Epithelial Cells from Patients with COPD

https://pubmed.ncbi.nlm.nih.gov/37228294/
Reddy-Vari H, Kim Y, Rajput C and Sajjan U. Increased Expression of miR146a Dysregulates TLR2-Induced HBD2 in Airway Epithelial Cells from Patients with COPD. ERJ Open Res. 2023 May 22;9(3):00694-2022. PMID: 37228294; PMCID: PMC10204848. DOI: 10.1183/23120541.00694-2022. https://pubmed.ncbi.nlm.nih.gov/37228294/ 

Pellino1 Restricts Herpes Simplex Virus Infections in the Epidermis and Dissemination to Sebaceous Glands

https://pubmed-ncbi-nlm-nih-gov.libproxy.temple.edu/36216205/
Cai KQ, Shellhamer C, Akiyama T, Jensen LE. Pellino1 Restricts Herpes Simplex Virus Infections in the Epidermis and Dissemination to Sebaceous Glands. J Invest Dermatol. 2023 Apr;143(4):639-647.e2. doi: 10.1016/j.jid.2022.09.007. Epub 2022 Oct 8.PMID: 36216205 https://www-sciencedirect-com.libproxy.temple.edu/science/article/pii/S0022202X22019418?via%3Dihub

Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection

https://pubmed.ncbi.nlm.nih.gov/36351902/
Chen J, Deng JC, Zemans RL, Bahmed K, Kosmider B, Zhang M, Peters-Golden M, Goldstein DR. Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection. Nat Commun. 2022 Nov 9;13(1):6759. doi: 10.1038/s41467-022-34593-y. PMID: 36351902 https://pubmed.ncbi.nlm.nih.gov/36351902/ 

Molecular Framework of Mouse Endothelial Cell Dysfunction during Inflammation: A Proteomics Approach

https://pubmed.ncbi.nlm.nih.gov/35955534/
Rossi, M.T., Langston, J.C., Singh, N., Merali, C., Yang, Q., Merali, S., Prabhakarpandian, B., Kilpatrick, L.E and Kiani, M.F. Molecular Framework of Mouse Endothelial Cell Dysfunction during Inflammation: A Proteomic Approach. International Journal of Molecular Sciences, 2022 Jul 29;23(15):8399. doi: 10.3390/ijms23158399. PMID: 35955534 https://pubmed.ncbi.nlm.nih.gov/35955534/ 

Mitochondrial Ribosome Dysfunction in Human Alveolar Type II Cells in Emphysema

https://pmc.ncbi.nlm.nih.gov/articles/PMC9313339/
Karim L, Lin CR, Kosmider B, Criner G, Marchetti N, Bolla S, Bowler R, Bahmed K. Mitochondrial Ribosome Dysfunction in Human Alveolar Type II Cells in Emphysema Biomedicines. 2022 Jun 24;10(7):1497. doi: 10.3390/biomedicines10071497. PMID: 35884802. https://pmc.ncbi.nlm.nih.gov/articles/PMC9313339/ 

Melanin/melanin-like nanoparticles: As a naturally active platform for imaging-guided disease therapy

Melanin/melanin-like nanoparticles: As a naturally active platform for imaging-guided disease therapy
Zhou Z, Yan Y, Wang L, Zhang Q, Cheng Y, Melanin-like nanoparticles decorated with an autophagy-inducing peptide for efficient targeted photothermal therapy, Biomaterials, 2019, 203, 63-72. PMID: 30852424 https://pmc.ncbi.nlm.nih.gov/articles/PMC10755544/

Expression of SARS-CoV-2 Entry Factors in Human Alveolar Type II Cells in Aging and Emphysema

https://pmc.ncbi.nlm.nih.gov/articles/PMC8301390/
Lin CR, Bahmed K, Simborio H, Hayek H, Bolla S, Marchetti N, Criner GJ, Kosmider B., Expression of SARS-CoV-2 Entry Factors in Human Alveolar Type II Cells in Aging and Emphysema. Biomedicines. 2021 Jul 6;9(7):779. doi: 10.3390/biomedicines9070779. PMID: 3435684318. https://pmc.ncbi.nlm.nih.gov/articles/PMC8301390/ 

Melanin-like nanoparticles loaded with an angiotensin antagonist for an improved photothermal cancer therapy

Melanin-like nanoparticles loaded with an angiotensin antagonist for an improved photothermal cancer therapy
Zhou Z, Yan Y, Zhang Q, Cheng Y, Melanin-like nanoparticles loaded with angiotensin antagonist for improved photothermal cancer therapy, Biomater. Sci., 2020, 8, 1658-1668. PMID: 31971526 https://pubmed.ncbi.nlm.nih.gov/31971526/

Targeted polyelectrolyte complex micelles treat vascular complications in vivo

Targeted polyelectrolyte complex micelles treat vascular complications in vivo
Zhou Z, Yeh CF, Mellas M, Oh MJ, Zhu J, Li J, Huang RT, Harrison D, Shentu TP, Wu D, Lueckheide M, Carver L, Chung EJ, Leon L, Yang KC, Tirrell MV, Yun Fang, Targeted polyelectrolyte complex micelles treat vascular complications in vivo, PNAS, 2021, 118, e2114842118. PMID: 34880134
https://pubmed.ncbi.nlm.nih.gov/34880134/

Protein kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis

https://pubmed.ncbi.nlm.nih.gov/31908004/
Liverani, E., Tursi, S.A., Cornwell, W.D., Mondrinos, M.J., Sun, S., Buttaro, B.A., Wolfson, M.R., Rogers, T.J., Tükel, Ç. and Kilpatrick, L.E. Protein Kinase C-delta Inhibition is Organ-Protective, Enhances Pathogen Clearance and Improves Survival in Sepsis. The FASEB Journal, Feb;34(2):2497-2510. doi: 10.1096/fj.201900897R. Epub 2019 Dec 23. PMID: 31908004 https://pubmed.ncbi.nlm.nih.gov/31908004/