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Carmen Sapienza, PhD

Research involves the genetics of parental-origin effects (why some genes behave differently when inherited from mothers than when inherited from fathers) and on genetic factors that influence chromosome segregation (the process that ensures that each cell receives the proper type and number of chromosomes). Both of these processes depend on the interaction of specific sets of proteins with specific DNA sequences and aberrations in these interactions can lead to many diseases, including cancer. We investigate these effects in both animal models (the mouse) as well as the human population. Work is funded by the National Institutes of Health.