Research Interests
Research in Kishore laboratory is focused on several specific areas within the overall theme of identifying novel insights into cardiovascular disease mechanisms and the translational integration of mechanistic studies in relevant physiological models. The major focus of ongoing research encompasses investigations into multiple approaches to enhance cardiovascular repair and regeneration after post-myocardial infarction. These approaches include the use of adult and pluripotent stem cells, stem cell-derived extracellular vesicles/exosomes, anti-inflammatory cytokines, novel noncoding RNAs such as circular RNAs and microRNAs and epigenetic modification of cells as some of the tools to enhance repair and regeneration of injured myocardium. Laboratory is currently investing significant efforts on developing stem cell-derived exosomes as novel cell-free alternate to stem cell-based therapies for cardiac repair. Focus of these studies is to not only test the therapeutic efficacy of stem cell exosomes in mouse models of myocardial infarction but to also understand their mechanism of action and to investigate how microenvironment and genetic factors such as diabetes, systemic inflammation, gender and age etc. affect the reparative activity of stem cells as well as their exosome derivatives. Multiple other active projects in the laboratory include studies on diabetes induced endothelial cell dysfunction, epigenetic regulation of stem cell function, identification of novel noncoding RNAs such as circular-RNAs in mediating cardiac injury and repair response, gene and mRNA based therapeutics to enhance cardiomyocyte renewal and heart repair.
Education, Training & Credentials
- PhD, University of Lucknow, 1995
- MD, University of Lucknow, 1988
- Undergraduate Degree, University of Lucknow, 1986
Memberships
- American Association of Immunologists
- American Heart Association
- American Stroke Association
- Research Society on Alcoholism
- American Association for the Advancement of Science