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Lewis Katz School of Medicine

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Suhail Akhtar, PhD

Suhail Akhtar, PhD

Suhail Akhtar, PhD

  • Lewis Katz School of Medicine

    • Biomedical Education and Data Science

      • Associate Professor

RESEARCH INTERESTS

  • Intestinal inflammation, gut microbiota, effects of dietary supplements on gut health

EDUCATION

  • Ph.D. (Biochemistry): Aligarh Muslim University, India
  • M.S (Biotechnology): Aligarh Muslim University, India
  • B.S (Biochemistry): Aligarh Muslim University, India

PUBLICATIONS

1. Avina J, Ahmad Z, Malik A, Siddiqui MR, Akhtar S. Vitamin D3 attenuates lipopolysaccharide-induced necroptosis in caco-2 cells. In preparation for submission to Applied Biochemistry and Biotechnology.

2. Skinner AG, Malik A, Siddiqui MR, Singh V, Akhtar S. Inulin protects Caco-2 cells against lipopolysaccharide-induced epithelial barrier dysfunction. Food Science & Nutrition, 24;13(4):e70046 PMID: 40129999

3. Liza, Hussain G, Malik A, Akhtar S, Anwar H. (2024) Artemisia vulgaris extract as a novel therapeutic approach for reversing diabetic cardiomyopathy in a rat model. Pharmaceuticals 8;17(8):1046 PMID: 39204151

4. Subramaniam S, Bu HF, Chou PM, Wang X, Geng H, Akhtar S, Du C, Tan SC, Ideozu JE, Tulluri A, Sun Y, Ding WX, De Plaen IG, Tan XD (2024) Scattered crypt intestinal epithelial cell apoptosis induces necrotizing enterocolitis via intricate mechanisms. Cell Mol Gastroenterol Hepatol. 18 (3): 10134. PMID: 38788898

5. Loying S, Sarmah R, Sarma MP, Malik A, Akhtar S, Khan AA, Nayak R, Saikia D. (2024) Essential oils of indigenous citrus varieties of Northeast India as potential antibiofilm agents against foodborne pathogens: An in vitro and in silico study. Czech J Food Sci 42(3) 153-162

6. Iftikhar A, Nausheen R, Khurshid M, Iqbal RK, Muzaffar H, Malik A, Ali Khan A, Batool F, Akhtar S, Yasin A, Anwar H. (2023) Pancreatic regenerative potential of manuka honey evidenced through pancreatic histology and levels of transcription factors in diabetic rat model. Heliyon. Sep 9; 9 (9):e20017. PMID: 37809953

7. Priyamvada S, Akhtar S. (2023) Editorial: Gut physiology-microbes and inflammatory diseases. Front Physiol. Jul 21; 14: 1254228. PMID: 37546537

8. Arshad R, Arshad MS, Malik A, Alkholief M, Akhtar S, Tabish TA, Moghadam AA, Rahdar A, Diez-Pascual AM. (2023). Mannosylated preactivated hyaluronic acid-based nanostructures for bacterial infection treatment. International Journal of Biological Macromolecules, 6: 124741. PMID: 37156311

9. Lakhani M, Azim S, Akhtar S, Ahmad, Z. (2022). Inhibition of Escherichia coli ATP synthase and cell growth by dietary pomegranate phenolics. International Journal of Biological Macromolecules, 213: 195-209.

10. Thomas A, Sumughan S, Dellacecca ER, Shivde RS, Lancki N, Mukhatayev Z, Vaca C, Han F, Barse L, Henning S, Zamora-Pineda J, Akhtar S, Gupta N, Zahid JO, Zack S, Ramesh P, Jaishankar D, Lo A, Moss J, Picken MM, Darling TN, Scholtens DM, Dilling DF, Junghans RP, Le Poole IC. (2021) Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice. JCI Insight 6(22):e152014. PMID: 34806651

11. Dellacecca ER, Cosgrove C, Mukhatayev Z, Akhtar S, Engelhard VH, Rademaker AW, Knight K, LePoole IC. (2020) Antibiotics drive microbial imbalance and vitiligo development in mice. J Invest Dermatol 140: 676-687. PMID: 31472106

12. Younge N, McCann JR, Ballard J, Plunkett C, Akhtar S, Araújo-Pérez F, Murtha A, Brandon D, Seed PC. Fetal exposure to the maternal microbiota in humans and mice. (2019) JCI Insight 4(19): e127806. PMID: 31479427

13. Siddiqui MR, Akhtar S, Shahid M, Tauseef M, McDonough K, Shanley TP. miR-144 mediated inhibition of ROCK1 protects against LPS-induced lung endothelial hyperpermeability. (2019) Am J Respir Cell Mol Biol 61(2): 257-265. PMID: 30811958

14. Cannon AR, Akhtar S, Hammer AM, Morris NL, Javorski MJ, Li X, Kennedy RH, Gamelli RL, Choudhry MA. Effects of mesalamine treatment on gut barrier integrity following burn injury. J Burn Care Res 37(5): 283-292, 2016. PMID: 27388883

15. Wang P, Du C, Chen FX, Li CQ, Yu YB, Han T, Akhtar S, Zuo XL, Tan XD, Li YQ. BDNF contributes to IBS-like colonic hypersensivity via activating the enteroglia-nerve unit. Scientific Reports 6:20320, 2016. PMID: 26837784

16. Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, Hammer AM, Morris NL, Li X, Eberhardt JM, Gamelli RL, Kennedy RH, Choudhry MA. Burn injury alters the intestinal microbiome and increases gut permeability and bacterial translocation. PLoS One 10(7): e0129996, 2015. PMID: 26154283

17. Jabir NR, Firoz CK, Baeesa SS, Ashraf GM, Akhtar S, Kamal W, Kamal MA, Tabrez S. Synopsis on the linkage of Alzheimer's and Parkinson's disease with chronic diseases. CNS Neurosci Ther Jan; 21(1):1-7, 2015. PMID: 25399848

18. Sigman M, Conrad P, Rendon JL, Akhtar S, Eberhardt J, Gamelli RL, Choudhry MA. Noninvasive measurement of intestinal inflammation after burn injury. J Burn Care Res 34(6): 633638, 2013. PMID: 23511286

19. Rendon JL, Li X, Akhtar S, Choudhry MA. IL-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury. Shock 39(1): 11-18, 2013. PMID: 23143063

20. Akhtar S. Alcohol, gut microbiota and epithelial barrier: An interdependent relationship. Editorial published in J Alcoholism Drug Depend Mar 2013, Vol. 1, Issue 2.

21. Li X, Rendon JL, Akhtar S, Choudhry MA. Activation of TLR2 prevents suppression of T cell IFN-γ production by modulating p38/ERK pathways following alcohol and burn injury. Mol Med. 18: 982-991, 2012. PMID: 22634720

22. Li X, Akhtar S, Choudhry MA. Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Biochim Biophys Acta 1822(2): 196-203, 2012. PMID: 22001439

23. Akhtar S, Li X, Kovacs EJ, Gamelli RL, Choudhry MA. Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury. Mol Med 17(1-2): 88-94, 2011. PMID: 20844839

24. Li X, Akhtar S, Kovacs EJ, Gamelli RL, Choudhry MA. Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury. J Burn Care Res 32(4): 489-97, 2011. PMID: 21593683

25. Akhtar S, Li X, Chaudry IH, Choudhry MA. Neutrophil chemokines and their role in IL-18mediated increase in neutrophil O2‾ production and intestinal edema following alcohol intoxication and burn injury. Am J Physiol Gastrointest Liver Physiol. 297: G340-7, 2009. PMID: 19497959

26. Akhtar S, Meeran SM, Katiyar N, Katiyar SK. Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation and angiogenic factors. Clin Cancer Res, 15(3): 821-31, 2009. PMID: 19188152

27. Meeran SM, Akhtar S, Katiyar SK. Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation. J Invest Dermatol, 129(5): 1258-70, 2009. PMID: 19020550

28. Katiyar SK, Meeran SM, Katiyar N, Akhtar S. p53 cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol Carcinog, 48: 24-37, 2009. PMID: 18459128

29. Akhtar S, Husain Q. Potential applications of immobilized bitter gourd (Momordica charantia) peroxidase in the removal of phenols from polluted water. Chemosphere, 65: 1228-35, 2006. PMID: 16764905

30. Khan AA, Akhtar S, Husain Q. Direct immobilization of polyphenol oxidases on Celite-545 from ammonium sulphate fractionated proteins of potato (Solanum tuberosum). J Mol Catal B: Enzymatic, 40: 58-63, 2006. DOI: 10.1016/j.molcatb.2006.03.001

31. Akhtar S, Khan AA, Husain Q. Simultaneous purification and immobilization of bitter gourd (Momordica charantia) peroxidases on bioaffinity support. J Chem Technol Biotech, 80: 198-205, 2005. DOI: 10.1002/jctb.1179

32. Akhtar S, Khan AA, Husain Q. Potential of immobilized bitter gourd (Momordica charantia) peroxidases in the decolorization and removal of textile dyes from polluted wastewater and dyeing effluent. Chemosphere, 60: 291-301, 2005. PMID: 15924947

33. Akhtar S, Khan AA, Husain Q. Partially purified bitter gourd (Momordica charantia) peroxidase catalyzed decolorization of textile and other industrially important dyes. Biores Technol, 96: 1804-1811, 2005. PMID: 16051087

34. Khan AA, Akhtar S, Husain Q. Simultaneous purification and immobilization of mushroom tyrosinase on immunoaffinity support. Process Biochem, 40: 2379-2386, 2005. DOI: 10.1016/j.procbio.2004.09.020

35. Khan AA, Akhtar S, Husain Q. Adsorption of polyphenol oxidases on Celite-545 directly from ammonium sulphate fractionated proteins of brinjal (Solanum melongena). J Sci Indust Res, 64: 621-626, 2005. http://nopr.niscair.res.in/handle/123456789/5115

36. Deeba F, Nasti TH, Sharma S, Ahmad N, Akhtar S, Saleemuddin M, Owais M. Phospholipid diversity: Correlation with membrane-membrane fusion events. BBABiomembranes, 1669: 170-181, 2005. DOI: 10.1016/j.bbamem.2005.02.009

37. Meeran SM, Akhtar S, Khan AA, Husain Q. An economical, simple and high yield procedure for the immobilization/stabilization of peroxidases from turnip roots. J Sci Indust Res, 63: 540-547, 2004. http://nopr.niscair.res.in/handle/123456789/5456