Ovarian-Specific Cyp17A1 Overexpression in Female Mice: A Novel Model of Endogenous Testosterone Excess
Joseph S, Ubba V, Wang Z, Feng M, dSilva MK, Suero S, Waheed D, Snyder NW, Yang X, Wang H, Richards JS, Ko CJ, Wu S*. Endocrinology. 2025 Mar 24;166(5). PMID: 40208112, IF.3.8
High impact publications from the Center.
Faculty in the CMDR conduct multidisciplinary research that explores mechanisms underlying metabolic and degenerative disorders, including hyperhomocysteinemia (HHcy), hyperlipidemia, hyperandremia, diabetes, obesity, vascular inflammation, hypertension, thrombosis, stroke, atherosclerosis, aortic stenosis, cardiovascular disease (CVD), chronic kidney disease (CKD), acute kidney injury (AKI), metabolic dysfunction-associated steatotic liver disease (MASLD), Alzheimer's disease (AD) and polycystic ovary syndrome (PCOS). We have had the following representative publications in the past five years.
Ovarian-Specific Cyp17A1 Overexpression in Female Mice: A Novel Model of Endogenous Testosterone Excess
Integrative single-cell and bulk RNA-seq analysis identifies CD4+ T cell subpopulation infiltration and biomarkers of T regulatory cells for mediating the progression of atherosclerotic plaque
Integrative single-cell and bulk RNA-seq analysis identifies CD4+ T cell subpopulation infiltration and biomarkers of T regulatory cells for mediating the progression of atherosclerotic plaque
Zhang Y, Qiu L, Qin M, Shan D, Lu S, Xie L, Yi Y, Yu J. Front. Immunol. 2025, 15:1528475. doi: 10.3389/fimmu.2024.1528475 PMID: 39896809 PMCID: PMC11781991 IF.5.9
Edgeworthia gardneri (Wall.) Meisn protects against HFD-induced murine atherosclerosis through improving gut microbiota-mediated intestinal barrier integrity
Edgeworthia gardneri (Wall.) Meisn protects against HFD-induced murine atherosclerosis through improving gut microbiota-mediated intestinal barrier integrity
Tang L, Li J, Luan M, Qin M, Zhong C, Zhang Y, Xie Y, Shi M, Qiu L, and Yu J. Atherosclerosis. 2025, 403:119132. DOI: 10.1016/j.atherosclerosis.2025.119132. PMID: 40015156 IF.5.7
Therapeutic potential of natural flavonoids in atherosclerosis through endothelium-protective mechanisms: An update
Therapeutic potential of natural flavonoids in atherosclerosis through endothelium-protective mechanisms: An update
Zhong C, Deng K, Lang X, Shan D, Xie Y, Pan W, Yu J. Pharmacol Ther. 2025, 271:108864. doi.org/10.1016/j.pharmthera.2025.108864 IF.12
SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome
SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome
Cueto R, Shen W, Liu L, Wang X, Wu S, Mohsin S, Yang L, Khan M, Hu W, Snyder N, Wu Q, Ji Y, Yang XF, Wang H. Redox Biol. 2024 Apr 27:73:103139. PMID: 38696898, PMCID: PMC11070633 IF.11.9
Reproductive profile of neuronal androgen receptor knockout female mice with a low dose of DHT
Reproductive profile of neuronal androgen receptor knockout female mice with a low dose of DHT
Ubba V, Joseph S, Awe O, Jones D, Dsilva MK, Feng M, Wang J, Fu X, Akbar RJ, Bodnar BH, Hu W, Wang H, Yang X, Yang L, Yang P, Taib B, Ahima R, Divall S, Wu S*. Endocrinology. 2024 Jan 16;165(3). PMID: 38156784 IF.3.8
Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation
Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation
Chu S, Shan D, Yi X, Tang L, He L, Yang S, Feng Y, Zhang Y, and Yu J. Front. Immunol., 2024, 15; https://doi.org/10.3389/fimmu.2024.1412022. PMID: 38881898 PMCID: PMC11176519 IF.5.9
Neuronal Ar regulates glucose homeostasis and energy expenditure in lean female mice with androgen excess.
Neuronal Ar regulates glucose homeostasis and energy expenditure in lean female mice with androgen excess.
Ubaa V, Joseph S, Awe O, Jones D, Dsilva MK, Feng M, Wang J, Fu X, Akbar RJ, Bodnar BH, Hu W, Wang H, Yang X, Yang L, Yang P, Ahima R, Divall S, Wu S*. Endocrinology. 2023 Sep 23;164(11). PMID: 37738624. IF.3.8
RNA-binding protein LIN28a regulates new myocyte formation in the heart via lncRNA-H19.
RNA-Binding Protein LIN28a Regulates New Myocyte Formation in the Heart Through Long Noncoding RNA-H19.
Rigaud VOC, Hoy R, Kurian J, Zarka C, Behanan M, Brosious I, Pennise J, Patel T, Wang T, Johnson J, Kraus L, Mohsin S, Houser SR, Khan M‡. Circulation 2023 Jan 24;147(4):324-337. PubMed PMID: 36314132; PMCID: PMC9870945. IF.37.8
Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer's disease.
Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer's disease.
Wang X, Liu L, Jiang X, Saredy J, Xi H, Cueto R, Sigler D, Khan M, Wu S, Ji Y, Snyder NW, Hu W, Yang X, Wang H. Alzheimers Res Ther. 2023 Oct 3;15(1):164. PMID: 37789414, PMCID: PMC10546779 IF.7.6
Isolation of Conditionally Immortalized Mouse Glomerular Endothelial Cells with Fluorescent Mitochondria
Isolation of Conditionally Immortalized Mouse Glomerular Endothelial Cells with Fluorescent Mitochondria
Rihab Bouchareb, Liping Yu, Emelie Lassen, Ilse S. Daehn. JoVE. September 13th, 2022. DOI:10.3791/64147. IF.3.8
UCP2 modulated cardiomyocyte cell cycle activity, acetyl-CoA and histone acetylation in response to moderate hypoxia
UCP2 modulated cardiomyocyte cell cycle activity, acetyl-CoA and histone acetylation in response to moderate hypoxia.
Rigaud VOC, Zarka C, Kurian J, Harlamova D, Elia A, Kasatkin N, Johnson J, Behanan M, Kraus L, Pepper H, Snyder NW, Mohsin S, Houser SR, Khan M‡. JCI Insight. 2022 Aug 8;7(15). PubMed PMID: 35771638; PMCID: PMC9462500. IF.6.1
Adaptive Immune Response Signaling Is Suppressed in Ly6C high Monocyte but Upregulated in Monocyte Subsets of ApoE -/- Mice - Functional Implication in Atherosclerosis
Adaptive Immune Response Signaling Is Suppressed in Ly6C high Monocyte but Upregulated in Monocyte Subsets of ApoE -/- Mice - Functional Implication in Atherosclerosis.
Yang P, Wu Q, Sun L, Fang P, Liu L, Ji Y, Park JY, Qin X, Yang X, Wang H. Front Immunol. 2021 Dec 20; 12:809208. PMID: 34987524, PMCID: PMC8721109 IF.5.9
Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells
Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells.
Jan M, Cueto R, Jiang X, Lu L, Sardy J, Xiong X, Yu JE, Pham H, Khan M, Qin X, Ji Y, Yang XF, Wang H. Redox Biol. 2021 Sep; 45:102018. PMID: 34140262 PMCID: PMC8282538 IF.11.9
Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint
Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint.
Tang T, Cheng X, Truong B, Sun L, Yang X, Wang H. Pharmacol Ther. 2021 Mar; 219:107709. PMID: 33091428, PMCID: PMC7886970 IF.12
Platelets: Implications in aortic valve stenosis and bioprosthetic valve dysfunction from pathophysiology to clinical care
Platelets: Implications in aortic valve stenosis and bioprosthetic valve dysfunction from pathophysiology to clinical care.
Stephanie L. Sellers, Gaurav S. Gulsin, Devyn Zaminski, Rong Bing, Azeem Latib, MD, Janarthanan Sathananthan, Philippe Pibarot, Rihab Bouchareb. JACC Basic Transl Sci 2021 Nov 17;6(12):1007-1020. doi: 10.1016/j.jacbts.2021.07.008. IF.11.9
Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis
Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis.
Bouchareb R, Guauque-Olarte S, Snider J, Zaminski D, Anyanwu A, Stelzer P, Lebeche D. JACC Basic Transl Sci. 2021 Jan;6(1):25-39. doi: 10.1016/j.jacbts.2020.11.008. eCollection 2021 Jan. PubMed PMID: 33532664; PubMed Central PMCID: PMC7838057. IF.7.2
LIN28a induced metabolic and redox regulation promotes cardiac cell survival in the heart after ischemic injury
LIN28a induced metabolic and redox regulation promotes cardiac cell survival in the heart after ischemic injury.
Yuko AE, Carvalho Rigaud VOC, Kurian J, Lee JH, Kasatkin N, Behanan M, Wang T, Luchesse AM, Mohsin S, Koch WJ, Wang H, Khan M‡. Redox Biol. 2021 Nov;47:102162. PubMed PMID: 34628272; PMCID: PMC8515487. IF.11.9
HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease
HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease.
Wei J#, Harada BT, Lu D, Ma R, Gao B, Xu Y, Montauti E, Mani N, Chaudhuri SM, Gregory S, Weinberg SE, Zhang DD, Green R, He C, Fang D#. Mol Cell. 2021 Dec 16;81(24):5052-5065.e6. PMID: 34847358; (# corresponding author) IF.16.6
MAP kinase phosphatase-5 deficiency protects against pressure overload-induced cardiac fibrosis
MAP kinase phosphatase-5 deficiency protects against pressure overload-induced cardiac fibrosis.
Zhong C†, Min K†, Zhao Z, Zhang C, Gao E, Huang Y, Zhang X, Baldini M, Roy R, Yang XF, Koch WJ, Bennett AM, Yu J.. Front. Immunol. 2021, DOI: doi.org/10.3389/fimmu.2021.790511. PMID: 34992607 PMCID: PMC8724134 IF.5.9