Thomas Rogers, PhD
Director, Center for Inflammation, Translational and Clinical Lung Research
Professor, Fels Institute for Cancer Research and Molecular Biology
- Contact Information
- About Me
Our basic research interests have centered on an understanding of the cross-talk between G protein-coupled receptors (GPCRs) at the level of both protein function and gene expression. We have focused our attention on chemokine, opioid, and formyl peptide receptors because these groups of receptors play a significant role in the regulation of inflammatory responses.
First, the capacity of these receptors to regulate the expression other GPCRs and their cognate ligands; and second, the cross-talk between opioid and chemokine receptor at the level of protein function. Our studies show that activation of certain GPCRs induces the expression of several chemokines and chemokine receptors, including those chemokines that perform critical pro-inflammatory functions. In contrast, there is a category of GPCRs which mediates anti-inflammatory responses by directly inhibiting the expression of pro-inflammatory chemokines and/or their receptors.
Second, we have found that several of the GPCRs are capable of the cross-regulation of other GPCRs through a process termed “heterologous desensitization". This process occurs when one GPCR is activated by its ligand and induces a signaling pathway which leads to the inactivation of a second, and distinct, GPCR. Our current work suggests that it should be possible to utilize the process of heterologous desensitization to devise strategies to develop treatment therapies for a number of important disease states.
- Education, Training & Credentials
- PhD, University of Wisconsin, Madison