Raj Kishore, PhD
Director, Stem Cell Therapy Program, Center for Translational Medicine
Associate Director and Professor, Center for Translational Medicine
Professor, Cardiovascular Sciences
Professor, Lemole Center for Integrated Lymphatics Research
- Contact Information
- About Me
Research in Kishore laboratory is focused on several specific areas within the overall theme of identifying novel insights into cardiovascular disease mechanisms and the translational integration of mechanistic studies in relevant physiological models. The major focus of ongoing research encompasses investigations into multiple approaches to enhance cardiovascular repair and regeneration after post-myocardial infarction. These approaches include the use of adult and pluripotent stem cells, stem cell-derived extracellular vesicles/exosomes, anti-inflammatory cytokines, novel noncoding RNAs such as circular RNAs and microRNAs and epigenetic modification of cells as some of the tools to enhance repair and regeneration of injured myocardium. Laboratory is currently investing significant efforts on developing stem cell-derived exosomes as novel cell-free alternate to stem cell-based therapies for cardiac repair. Focus of these studies is to not only test the therapeutic efficacy of stem cell exosomes in mouse models of myocardial infarction but to also understand their mechanism of action and to investigate how microenvironment and genetic factors such as diabetes, systemic inflammation, gender and age etc. affect the reparative activity of stem cells as well as their exosome derivatives. Multiple other active projects in the laboratory include studies on diabetes induced endothelial cell dysfunction, epigenetic regulation of stem cell function, identification of novel noncoding RNAs such as circular-RNAs in mediating cardiac injury and repair response, gene and mRNA based therapeutics to enhance cardiomyocyte renewal and heart repair.
- Education, Training & Credentials
- PhD, University of Lucknow, 1995
- MD, University of Lucknow, 1988
- Undergraduate Degree, University of Lucknow, 1986
- American Association of Immunologists
- American Heart Association
- American Stroke Association
- Research Society on Alcoholism
- American Association for the Advancement of Science
Srikanth GVN, Krishnamurthy P, Verma SK, Kishore R. Endothelial Progenitor Cells: Application in Vascular Medicine. In Stem Cell Therapy for Organ Failures; Eds. S Indumathi; Springer; 2014 (in Press).
Kishore R, McMullen MR, Cocuzzi E, and Nagy LE. Stabilization of TNF-alpha mRNA contributes to increased lipopolysaccharide-stimulated TNF-alpha production by Kupffer cells after chronic ethanol feeding. Cells of the Hepatic Sinusoid. Eds E Wisse and R Knook; 23-27, 2003.
Kishore R and DW Losordo. Human Bone Marrow Derived Cells and Myocardial Repair and Regeneration. Leri A, Anversa P, Frishman eds Cardiac Regeneration and Stem Cell Therapy, Blackwell publications, pp178-86, 2007.
Kishore R and Hoxha E. Induced Pluripotent Cells in cardiovascular Biology: Epigenetics, Promises and Challenges. In Conn P. Michael, Tang Y (eds.) Progress in Molecular Biology and Translational Science, Vol. 111: Genetics of Stem cells, Elsevier Inc. Publishers: 1-25, 2013.
Krishnamurthy P, Verma SK, Kishore R. Murine Bone marrow Transplantation Model. In Bolli R, Losordo DW, Ardehali H (eds), Manual of Research Techniques in Cardiovascular Medicine; Wiley-Blackwell publishers, Oxford, UK, 2013 (in press).
Verma SK, Krishnamurthy P, Kishore R. Transverse Aortic Constriction: A Model to Study Heart Failure in small animals. In Bolli R, Losordo DW, Ardehali H (eds), Manual of Research Techniques in Cardiovascular Medicine; Wiley-Blackwell publishers, Oxford, UK, 2013 (in press).
Thal MA and Kishore R. Role of cytokines in angiogenesis: Turning it on and off. In, Mehta J and Dhalla s (eds) Biochemical basis of Angiogenesis; Springer Science publishers, pp: 25-51; 2013.
Lambers E and Kishore R. mRNA Stability in cardiac Function and Disease. Current Hypertension Reports: Mediators, Mechanisms and pathways in Tissue Injury section. Volume 14, issue 6, 2013 (in press).
24711449. P Sasi S, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 Signaling Inhibits Early and Increases Delayed Non-Targeted Effects in Bone Marrow-Derived Endothelial Progenitor Cells. J Biol Chem. 2014 Apr 12. [Epub ahead of print]