Erica A. Golemis, PhD

Research Interests

• Cancer research
• Translational research on solid tumors; focus on head and neck cancer, lung cancer, and colorectal cancer
• Cell signaling networks

About

My laboratory, located at the Burholme Campus of Fox Chase Cancer Center and the LKSOM, evaluates signaling networks governing carcinogenesis and ciliopathies. During, my graduate studies at MIT, I combined bioinformatic analysis with targeted mutagenesis to dissect enhancer core for mammalian leukemia-inducing retroviruses, in work that provided groundwork for the discovery of the key RUNX/AML leukemic regulators. As a postdoctoral fellow at Massachusetts General Hospital and Harvard Medical School, and in my own laboratory, I was lead developer of a yeast two-hybrid system that for a decade served a major platform for the identification of protein-protein interactions and protein signaling networks. As an independent researcher, my group has focused on definition of signaling networks related to drug resistance, with specific emphasis on study of AURKA, NEDD9, and associated proteins that regulate cell cycle, genome stability, and cell-cell communication via cilia. Researchers in my laboratory have extensive experience in bioinformatic analysis of protein interaction and genomic datasets, which we have used in collaborative studies with clinical partners to evaluate factors influencing prognosis for several types of solid tumors, including lung, head and neck, and colon. I also serve as Director as the High Throughput Screening Facility at Fox Chase Cancer Center, and have expertise in probing chemical and small molecule libraries to identify cancer-relevant modulators. Additional information is available at https://www.foxchase.org/erica-golemis.

Educational Background

• PhD, Biology, Massachusetts Institute of Technology, Cambridge, MA

Memberships

• American Association for Cancer Research (AACR)
• American Association for the Advancement of Science (AAAS)
• American Society for Cell Biology (ASCB)

Honors & Awards

• Fellow, American Association for the Advancement of Science, 2019
• William Wikoff Smith Foundation, Endowed Chair in Cancer Research, 2019
• Award for Translational Science, Temple University School of Medicine, 2014
• Award for Scientific Accomplishment, American Cancer Society, Southeast Pennsylvania, 2011

Digital Bibliography

View Digital Bibliography

Additional Publications

Protein Interactions, flagship laboratory manual for a Molecular Cloning series, series editor J. Sambrook, volume editor E. Golemis, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 2002, 682 pp.

E. Golemis and J. Chernoff, Editors, Methods, issue entitled “”Analysis and Manipulation of Intracellular Signaling Cascades”. 32(4), April 2004. Protein-Protein Interactions, Second Edition: a Molecular Cloning Manual. Eds. Golemis, E.A. and Adams, P.D., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 938 pages, 2005.

Simpson, R.J., Adams, P.D., and Golemis, E.A., eds., “Basic Methods in Protein Purification and Analysis”, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY., 436 pages, 2008.

B. Burtness and E.A. Golemis. Molecular Determinants of Head and Neck Cancer. Current Cancer Research Series, Springer Press, New York, 362 pages, 2014.

B. Burtness and E.A. Golemis. Second Edition, Molecular Determinants of Head and Neck Cancer, Springer Press, New York, 628 pages, 2018.