Charu Rajput, PhD
Instructor, Center for Inflammation and Lung Research (CILR)
- About Me
The focus of my research is on airway epithelial host defense mechanisms, immune cell activation and inflammation in response to respiratory virus and bacterial infections in COPD. Most exacerbations of COPD are caused by respiratory tract infections, with high mortality rates, hence there is a need for better therapeutic strategies. My work combines airway epithelial cell culture from normal and diseased donor lungs, mouse models and human subjects to study the underlying mechanisms. Our current research aims to understand the contribution of dipeptidyl peptidase 4 (DPP4), a serine peptidase, in inducing inflammation and exacerbations in COPD, as well as understanding the role of innate immune cells such as innate lymphoid cells and macrophage subsets in COPD pathogenesis.
I am also interested in investigating the role of rhinovirus in asthma development. Evidence suggests that wheezing with viral infections, particularly respiratory syncytial virus (RSV) and rhinovirus (RV) predisposes infants and young children to develop asthma later in life. My previous studies showed that early life rhinovirus infection triggers expansion of IL-13 producing type 2 innate lymphoid cells which are required and sufficient for causing an asthma like phenotype and mucous metaplasia in immature mice. On the other hand, we found that IL-17 producing type 3 innate lymphoid cells and gd T cells were increased in rhinovirus and enterovirus D68 infected adult mice. My future studies will examine the mechanisms which pre-dispose children to rhinovirus infection induced asthma development.
- Education, Training & Credentials
- PhD, Institute of Genomics and Integrative Biology, New Delhi, India
- American Thoracic Society