In This Section

Wenzhe Ho, MD, MPH

Professor, Pathology and Laboratory Medicine
Professor, Anatomy and Cell Biology
Professor, Center for Substance Abuse Research
Professor, Wuhan University

Wenzhe Ho
For Patients
Contact Information

Contact Information

Phone

215-707-8858

Fax

215-707-5255

Email

wenzheho@temple.edu
About Me

Research Interests

  • Innate immunity and viral infections (HIV and HCV)
  • Impact of drugs on host immunity related to HIV or HCV
  • Novel natural products against HIV

Techniques

  • Immunology
  • Virology
  • Molecular/cellular biology

Focuses

The Ho Laboratory studies factors that impact host cell innate immunity and viral infections, particularly HIV and HCV. The lab focuses on the following areas: 

1. To analyze the immune and bystander cells-mediated innate immunity against HIV or HCV, specifically the role of the sensors (TLR3/7/9 and RIG-I) of viral infection/replication in the induction of intracellular viral restriction factors and inhibition of HIV or HCV. The cells under examination include T cells, monocytes/macrophages, microglia, astrocytes, endothelial cells, epithelial cells, hepatocytes and stellate cells. The lab was among the firsts to demonstrate that the ordinary cells (bystanders) in the GI system and the CNS produce the cellular viral restriction factors that can inhibit HIV or HCV in the target cells;

2. To study whether the environment factors such as drugs (opioids, methamphetamine) of abuse impair host cell innate immunity and facilitate HIV or HCV infection. The lab has published a number of papers, showing that the drugs such as heroin, morphine and methamphetamine compromise the antiviral defense mechanisms and promote the viral replication;

3. To identify novel antiviral natural products against HIV. The lab has documented that EGCG, a major active component of green tea, has anti-inflammation and anti-HIV properties. In addition, the lab recently reported that BBI, a soybean-derived protease inhibitor, could effectively inhibit HIV infection of macrophages at several steps of viral replication. These findings provide scientific evidence to support further in vivo investigations on the therapeutic potential of the natural products for HIV prevention/treatment.

Education, Training & Credentials

Educational Background

  • MPH, University of Pennsylvania School of Medicine, Philadelphia, PA, 2006
  • Fellowship, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 1988
  • Residency, First Teaching Hospital, Wuhan University School of Medicine, Wuhan, China, 1986
  • MD, Pediatrics, Wuhan University School of Medicine, Wuhan, China, 1983
  • BS, Medicine, Hubei Medical College, Wuhan, China, 1978

Memberships

  • Society on NeuroImmune Pharmacology
  • International Society for NeuroVirology

Honors & Awards

  • Senior Research Excellence Award, Lewis Katz School of Medicine at Temple University, 2012
Publications

PubMed Publications

View PubMed Publications