In This Section

Vincent Tam, PhD

Assistant Professor, Microbiology and Immunology

Vincent Tam
Contact Information

Contact Information

Email

vincent.tam@temple.edu
About Me

Research Interests

My research focuses on the complex interplay between microbes and the host immune response. When confronted with pathogens, the immune system induces inflammation, altering the vasculature and triggering the infiltration of immune cells to the site of infection. Consequently, microbial pathogens have evolved mechanisms to evade host defenses at various stages of the inflammatory response. While the induction of inflammation is tightly regulated to ensure pathogen clearance, the resolution of inflammation is equally critical to avoid excessive tissue damage and detrimental inflammatory-mediated pathology, including autoimmune disease and cancer. My specific interest is to study the resolution stage, when the immune response is actively down-regulated during the return to homeostasis. I am investigating the molecular pathways driving this process as well as the mechanisms by which pathogens exploit the resulting vulnerability of the host, using models of influenza virus/Staphylococcus aureus super-infection. I will combine global systems biology approaches and targeted molecular methods to understand the interactions between microbial pathways and immune networks.

Education, Training & Credentials

Educational Background

  • Fellowship, Center for Infectious Disease Research, Seattle, WA, 2017
  • Fellowship, Institute for Systems Biology, Seattle, WA, 2011
  • Fellowship, Harvard Medical School, Boston, MA, 2009
  • PhD, Microbiology, Harvard Medical School, Boston, MA, 2008
  • BS, Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA, 2000

Memberships

  • American Society of Microbiologists
Publications

PubMed Publications

View PubMed Publications

Additional Publications

Alfano JR, Buell, CR, Chancey, ST, Collmer, A, Espinosa, S, Guo, M, Hanks, M, Jamir, Y, Janes, MD, Schneider, DJ, Shan, L, Petnicki-Ocwieja, T, Schechter, LM, Tam, VC, Tang, X. (2003). Genomic Mining Substrates of the Type III Secretion System of Pseudomonas syringae pv. tomato DC3000: New Insights into Mechanisms of Pathogenesis. Pseudomonas syringae and related pathogens: Biology and Genetic. NS Iacobellis, A Collmer, SW Hutcheson et al. Doredrecht, Springer Netherlands: 363-372.

Moen, S.O., Abendroth, J., Fairman, J.W., Baydo, R.O., Bullen, J., Kirkwood, J.L., Barnes, S.R., Raymond, A.C., Begley, D.W., Henkel, G., McCormack, K., Tam, V.C., Phan, I., Staker, B.L., Stacy, R., Myler, P.J., Lorimer, D., and Edwards, T.E. (2014). Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1. Scientific reports 4, 5944.

Zak, D.E., Tam, V.C., and Aderem, A. (2014). Systems-level analysis of innate immunity. Annual review of immunology 32, 547-577... Expand