Vincent Tam, PhD
Assistant Professor, Microbiology and Immunology
- Contact Information
- About Me
My research focuses on the complex interplay between microbes and the host immune response. When confronted with pathogens, the immune system induces inflammation, altering the vasculature and triggering the infiltration of immune cells to the site of infection. Consequently, microbial pathogens have evolved mechanisms to evade host defenses at various stages of the inflammatory response. While the induction of inflammation is tightly regulated to ensure pathogen clearance, the resolution of inflammation is equally critical to avoid excessive tissue damage and detrimental inflammatory-mediated pathology, including autoimmune disease and cancer. My specific interest is to study the resolution stage, when the immune response is actively down-regulated during the return to homeostasis. I am investigating the molecular pathways driving this process as well as the mechanisms by which pathogens exploit the resulting vulnerability of the host, using models of influenza virus/Staphylococcus aureus super-infection. I will combine global systems biology approaches and targeted molecular methods to understand the interactions between microbial pathways and immune networks.
- Education, Training & Credentials
- Fellowship, Center for Infectious Disease Research, Seattle, WA, 2017
- Fellowship, Institute for Systems Biology, Seattle, WA, 2011
- Fellowship, Harvard Medical School, Boston, MA, 2009
- PhD, Microbiology, Harvard Medical School, Boston, MA, 2008
- BS, Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA, 2000
- American Society of Microbiologists
Alam, A., Tam, V., Hamilton, E., and Dziejman, M. (2010). vttRA and vttRB Encode ToxR family proteins that mediate bile-induced expression of type three secretion system genes in a non-O1/non-O139 Vibrio cholerae strain. Infection and immunity 78, 2554-2570.
Faruque, S.M., Tam, V.C., Chowdhury, N., Diraphat, P., Dziejman, M., Heidelberg, J.F., Clemens, J.D., Mekalanos, J.J., and Nair, G.B. (2007). Genomic analysis of the Mozambique strain of Vibrio cholerae O1 reveals the origin of El Tor strains carrying classical CTX prophage. Proceedings of the National Academy of Sciences of the United States of America 104, 5151-5156.
Sevier, C.S., Kadokura, H., Tam, V.C., Beckwith, J. Fass, D. and Kaiser, C.A. (2005). The prokaryotic enzyme DsbB may share key structural features with eukaryotic disulfide bond forming oxidoreductases. Protein science: a publication of the Protein Society 14, 1630-1642.
van Dijk, K., Tam, V.C., Records, A.R., Petnicki-Ocwieja, T., and Alfano, J.R. (2002). The ShcA protein is a molecular chaperone that assists in the secretion of the HopPsyA effector from the type III (Hrp) protein secretion system of Pseudomonas syringae. Molecular microbiology 44, 1469-1481. Collapse