Victor Rizzo, PhD, FAHA
Professor, Biomedical Education and Data Science
Professor, Cardiovascular Research Center
Professor, Sol Sherry Thrombosis Research Center
Professor, Cardiovascular Sciences
- Contact Information
- About Me
The long-range goal of the Rizzo lab is to discover the molecular signaling mechanisms that contribute to endothelial dysfunction and associated cardiovascular diseases such as atherosclerosis and aneurysm formation. Past studies demonstrate the importance of caveolae organelles in regulating endothelial cell function. Our research program offers the opportunity to evaluate the physiologic and pathophysiologic roles of endothelial caveolae and caveolin in signaling and transport using modern techniques in microscopy, biochemistry, cell biology, molecular genetic and unique in vivo and in vitro methodological approaches to attenuate vascular disease initiation and/or progression.
- Education, Training & Credentials
- Postdoctoral Fellowship, Mechanotransduction, University of Pennsylvania, Philadelphia, PA
- Postdoctoral Fellowship, Caveolae, Harvard Medical School, Cambridge, MA
- PhD, Cell Biology, Angiogenesis, New Jersey Medical School
- BS, Biology, Farleigh Dickinson University
Rizzo V, Kim D, Duran WN and DeFouw DO: Ontogeny of microvascular permeability to macromolecules in the chick chorioallantoic membrane during normal angiogenesis. Microvasc. Res. 49:49-63, 1995.
Rizzo V, Kim D, Duran WN and DeFouw DO: Differentiation of the microvascular endothelium during normal angiogenesis and respiratory onset in the chick chorioallantoic membrane. Tissue and Cell 27:159-166, 1995.
Rizzo V and DeFouw DO: Capillary sprouts restrict macromolecular extravasation during normal angiogenesis in the chick chorioallantoic membrane. Microvasc. Res. 52:47-51, 1996.
Rizzo V, Shumko JZ and DeFouw DO: Degranulation of mast cells in the chick chorioallantoic membrane does not increase endothelial permselectivity during normal angiogenesis. Microcirculation 3:387-393, 1996.
Rizzo V and DeFouw DO: Mast cell activation accelerates the normal rate of angiogenesis in the chorioallantoic membrane. Microvasc. Res. 52:245-257, 1996.
Rizzo V and DeFouw DO: Microvascular permselectivity in the chick chorioallantoic membrane during endothelial cell senescence. Int.J. Microcirc. 17:75-79, 1997.
Rizzo V, Cruz A and DeFouw DO: Microvessels of the chorioallantoic membrane uniformly restrict albumin extravasation during angiogenesis and endothelial differentiation. Tissue and Cell 29:277-281, 1997.
Rizzo V, Sung A, Oh P, and Schnitzer JE. Rapid mechanotransduction in situ at the luminal cell surface of the microvascular endothelium and its caveolae. J. Biol. Chem. 273:26323-26329, 1998.
Rizzo V, McIntosh DP, Oh P, and Schnitzer JE. Flow activates eNOS in caveolae at the luminal cell surface of endothelium in situ with rapid caveolin dissociation and calmodulin association. J. Biol. Chem. 273:34724-34729. 1998.
Rizzo V and Schnitzer JE: In: Vascular endothelium: Mechanisms of Cell signaling. Ed. Catravas, J.D., Callow, A.D. and Ryan, U.S.; Role of Caveolae in mechanotransduction, IOS Press, NATO Science Series A, vol 308, pp.97-116, 1999. Collapse