Victor Rizzo, PhD, FAHA
Professor, Biomedical Education and Data Science
Professor, Cardiovascular Research Center
Professor, Sol Sherry Thrombosis Research Center
Professor, Cardiovascular Sciences
- Contact Information
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- About Me
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Research Interests
The long-range goal of the Rizzo lab is to uncover the molecular signaling mechanisms that contribute to vascular dysfunction and associated large vessel disease such as atherosclerosis and aneurysm formation. Our studies center on organelles and their role as signaling microdomains in endothelial and vascular smooth muscle cells. Past discoveries from the Rizzo lab have revealed that caveolae function as a hemodynamic flow-sensing and signal transducing organelles as well as redox signaling centers. This work has contributed to the current concept that caveolae serve as crucial regulatory elements that mediate vascular cell responses to pathogenic risk factors for cardiovascular disease (i.e., disturbed flow, inflammatory cytokines). More recent and ongoing projects focus on the role of mitochondrial and extracellular vesicle signaling in settings associated with both vascular heath and disease. Trainees are offered the opportunity to evaluate the physiologic and pathophysiologic processes of organelle signaling using modern techniques in microscopy, biochemistry, proteomics, cell biology and molecular genetic methodologies as well as unique in vivo and in vitro approaches.
- Education, Training & Credentials
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Educational Background
- Postdoctoral Fellowship, Mechanotransduction, University of Pennsylvania, Philadelphia, PA
- Postdoctoral Fellowship, Caveolae, Harvard Medical School, Cambridge, MA
- PhD, Cell Biology, Angiogenesis, New Jersey Medical School
- BS, Biology, Farleigh Dickinson University
- Publications
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Digital Bibliography