Yuri Persidsky, MD, PhD

Clinical Interests

• Surgical pathology
• Nephropathology
• Administration of clinical laboratories

Research Interests

• Molecular mechanisms regulating functions of blood brain barrier under physiologic and pathologic conditions (neuroinflammation, HIV-1 brain infection, alcohol and drug abuse)
• Pericyte dysfunction in blood brain barrier impairment caused by HIV infection
• Biomarkers of blood brain barrier injury
• Neuroprotective strategies based on diminution of neuroinflammation and blood brain barrier injury
• Effects of cannabinoids on neural stem cells

Research Projects

• Blood brain barrier injury in HIV infection complicated by diabetes: Mechanisms and protective strategies preventing cognitive impairment

• CNS injury caused by HIV-1 and alcohol: Protective effects of cannabinoid receptor 2 activation

• HIV-induced neuroinflammation associated with opioid abuse and tobacco smoke
• Secoisolariciresinol diglucoside to mitigate inflammation and toxicity in HIV associated dementia

Educational Background

• Residency, Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
• PhD, Pathology, Kiev Research Institute of Urology and Nephrology, Ukrainian Ministry of Health, Kiev, Ukraine
• MD, Bogomolets National Medical University, Kiev, Ukraine

Certifications

• Anatomic Pathology

Memberships

• College of American Pathologists
• American Society of Clinical Pathologists
• American Society for Investigative Pathology
• Society for NeuroImmune Pharmacology

Honors & Awards

• MERIT grant, National Institute on Alcohol Abuse and Alcoholism, 2010-2020
• Wybran award, Society on Neuroimmune Pharmacology, 2011

Digital Bibliography

View PubMed Publications

Books, Book Chapters, Monographs

Persidsky Y, Steffan AM, Gendrault JL, Berger S, Royer C, Hurtrel B, Stutte HJ, Aubertin AM, Kirn A: Involvement of liver sinusoidal cells at different stages of simian immunodeficiency virus (SIV) infection in macaques. In: Cells of the Hepatic Sinusoid, vol 5, Wisse, Knook, Wake, eds, Kupffer Cell Foundation, Leiden. The Netherlands. 1995; 33-36.

Persidsky Y, Steffan AM, Gendrault JL, Royer C, Aubertin AM, Kirn A: Morpho-functional changes of follicular dendritic cells (FDC) and lymph node structure in simian immunodeficiency virus (SIV) infection. In: Dendritic Cells in Fundamental and Clinical Immunology. Banchereau and Schmitt, eds, Plenum Press, New York. 1995; 329-331.

Persidsky Y, Gendelman HE: HIV-1 encephalitis is a consequence of viral infection and immune activation. In: Biology and Physiology of the Blood Brain Barrier (Couraud, Sherman, eds.), Plenum Press, New York, 1996; 365-367.

Persidsky Y, Tyor W: Nontransgenic murine animal model systems for the HIV-associated cognitive motor complex. In: Neurological and Neuropsychiatric Manifestations of HIV-1 Infection, Gendelman HE, Lipton S, Epstein L, Swidells S, eds. Chapman & Hall Publishers, NY 1997, pp. 168-178.

Gendelman HE, Ghorpade A, Persidsky Y: The neuropathogenesis of HIV-1 dementia. In: In Defense of the Brain, Peterson, Remington (eds.), Blackwell Sci, 1997, 290-304.

Persidsky, Y. Murine animal model systems for studies of HIV-1-associated dementia.  In:  The Neurology of AIDS, 2nd Edition.  Gendelman HE, Grant I, Lipton SA, Everall IP, Swindells S. (Eds.).  Oxford University Press, 2005, p. 289-296.

Persidsky Y. NeuroAIDS. In: Neuroimmune Pharmacology. Ikezu T, Gendelman HE, Kabanov AV, Pahan K, Pseborski S. (Eds). Springer, NY. 2008. 297-312.

Haorah J, Floreani NA, Persidsky Y. Alcohol-induced blood-brain barrier dysfunction. In: Research on the Neurobiology of Alcohol Use Disorders. Sher L. (Ed.). Nova Science Publishers, New York, 2008. p.239-260.  

Persidsky Y, Ramirez SH. The blood-brain barrier in the setting of neuroinflammation. In:  The Neurology of AIDS, 3rd Edition.  Gendelman, H.E., Grant, I., Lipton, S.A., Everall, I.P. and Swindells, S. (Eds.).  Oxford University Press, 2011, p. 220-230.

Persidsky Y, Ho WZ, Wang X, Potula R. Alcohol Abuse, HIV-1 and Hepatitis C Infection. Chapter 11. Neuro-Immune Effects of Alcohol. Springer. 2012, p. 509-534.

Persidsky Y, Gofman L, Potula R. Alcohol and Neurodegeneration. Chapter 24. Book “Neuroinflammation and Neurodegeneration”. Edited by Peterson PK and Toborek M. 2014, pp.511-528.

Merkel S, Ramirez SH, Persidsky Y. Blood brain barrier (BBB) dysfunction in HIV Infection. Chapter 3, Volume II Book “The Blood-Brain Barrier in Health and Disease”. 2015. Edited by Dorovini-Zis, K. CRC Press, Francis and Taylor.