In This Section

Lawrence Brent, MD

Professor, Clinical Medicine
Associate Director, Rheumatology Fellowship Program

Lawrence Brent
For Patients
About Me

Clinical Interests

  • Systemic lupus erythematosus 
  • Spondyloarthropathies: Ankylosing Spondylitis, Psoriatic Arthritis
  • Idiopathic Inflammatory Myopathies: Polymyositis, Dermatomyositis
  • Septic Arthritis 

Research Interests

  • Spondyloarthropathies 
  • Septic Arthritis 
Education, Training & Credentials

Educational Background

  • Fellowship, Rheumatology, Thomas Jefferson University Hospital, Philadelphia, PA, 1984
  • Residency, Internal Medicine, Thomas Jefferson University Hopsital, Philadelphia, PA, 1982
  • Internship, Internal Medicine, West Virginia University Hospital, Morgantown, WV, 1980
  • MD, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, 1979
  • BS, Penn State University, State College, PA, 1977


  • Internal Medicine
  • Rheumatology


  • Pennsylvania Rheumatology Society, Board of Directors, 2011-present
  • American Association of Immunologists, 1991-present
  • American Association for the Advancement of Science, 1991-present
  • Philadelphia Rheumatism Society, Board of Directors, 1987-present
  • American College of Rheumatology, Fellow, 1984-present
  • American College of Physicians, Fellow, 1982-present

Honors & Awards

  • Top Doctor in Rheumatology, Philadelphia Magazine, 2009 - 2017
  • Top Doctor, Super Doctors, 2012 and 2013
  • Top Doctor in Rheumatology, US News and World Report, 2011 and 2013
  • Joseph Lee Hollander, MD Award in the Field of Rheumatology, Arthritis Foundation, Eastern Pennsylvania Chapter, 2008


  • Rodriguez-Paez AC, Seetharaman M, Brent LH. Cryoglobulin crystal arthropathy in a patient with multiple myeloma. J Clin Rheumatol 2009;15:238-40. PMID: 19590446
  • Badawi R, Brent LH, Feinstein D. Mimics of vasculitis: vascular Ehlers-Danlos syndrome masquerading as polyarteritis nodosa. J Rheumatol 2009;36:1845-6. PMID: 19671829
  • Brent LH. Inflammatory arthritis: An overview for primary care physicians. Postgraduate Med 2009;121:148-62. PMID: 19332973
  • Shanmugam S, Brent LH. Sarcoid Arthropathy. J Rheumatol 2008;35:1892-3. PMID: 18785297
  • Feinstein DE, Brent LH. The complexity of the differential diagnosis for the inflammatory arthritides. Postgraduate Med 2006 (May Suppl);117:12-23. PMID: 17957858
  • Brent LH. Introduction: Inflammatory arthritis. Postgraduate Med 2006 (May Suppl); 117:3-4. PMID: 17957857
  • Lowry SM, Brent LH, Menaldine S, Kerr JR. A case of persistent parvovirus B19 infection with bilateral cartilaginous and ligamentous damage to the wrists. Clin Infect Dis 2005;41:e42-4. PMID: 16028146
  • Adusumilli SK, Brent LH. Bilateral shortening of the third and fourth metacarpal bones. J Clin Rheumatol 2005;11:109-11. PMID: 16357713
  • Kataria RK, Brent LH. Spondyloarthropathies. Am Fam Physician 2004;69:2853-60. PMID: 15222650
  • Kiratiseavee S, Brent LH. Spondyloarthropathies: Using presentation to make the diagnosis. Cleve Clin J Med 2004;71:184-206. PMID: 15055243
  • Kataria RK, Chaiamnuay S, Jacobson LD, Brent LH. Subacromial bursitis with rice bodies as the presenting manifestation of rheumatoid arthritis. J Rheumatol 2003;30:1354-5. PMID: 12784416
  • Seetharaman M, Brent LH. Ankylosing tarsitis. J Rheumatol 2003;30:630-1. PMID: 12610829
  • Viola IC, Joffe S, Brent LH. Primary hypertrophic osteoarthropathy. J Rheumatol 2000;27:1562-3. PMID: 10852293
  • Kovacs B, Lafferty TL, Brent LH, DeHoratius RJ. Transverse myelopathy in systemic lupus erythematosus: an analysis of 14 cases and review of the literature. Ann Rheum Dis 2000;59:120-4. PMID: 10666167
  • Tsiouris N, Kovacs B, Daskal I, Brent LH, Samuels A. End-stage renal disease in sarcoidosis of the kidney. Am J Kidney Dis 1999;34:E21. PMID: 10561161
  • Narag RB, Samuels AJ, Orlin SE, Brent LH. Polyarteritis nodosa complicated by severe progressive scleritis. J Rheumatol 1999;26:1213-4. PMID: 10333000
  • Brent LH, Beckman DA, Brent RL. Antirheumatic drugs: Their effects on reproductive health. Reprod Toxicol 1997;11:561-77. PMID: 9241677
  • Yamamoto N, Naraparaju VR, Moore M, Brent LH. Deglycosylation of serum vitamin D3- binding protein by -N-acetylgalactosaminidase detected in the plasma of patients with systemic lupus erythematosus. Clin Immunol Immmunopath 1997;82:290-8. PMID: 9073553
  • Brent LH, Rubenstein B, Gong QH, Wieland SJ. Transmembrane potential responses during HL-60 promyelocyte differentiation. J Cell Physiol 1996;168:155-65. PMID: 8647910
  • Brent LH, Gong Q, Ross JM, Wieland SJ. Mitogen activated Ca++ channels in human B lymphocytes. J Cell Physiol 1993;155:520-9. PMID: 8098335
  • Wieland SJ, Gong Q, Chou RH, Brent LH. A lineage-specific Ca++ activated K+ conductance in HL-60 cells. J Biol Chem 1992;267:15426-31. PMID: 1379229
  • Brent LH, Butler JL, Woods WT, Jr., Bubien JK. Transmembrane ion conductance in human B lymphocyte activation. J Immunol 1990;145:2381-9. PMID: 1698853
  • Brent LH, Miyawaki T, Everson MP, Butler JL. Interleukin-2 production by a marmoset B cell line. Euro J Immunol 1990;20:1125-9. PMID: 2162776
  • Brent LH, Abruzzo JL. Localized eosinophilic fasciitis in a patient with rheumatoid arthritis. J Rheumatol 1985;12:987-9. PMID: 4087274
  • Brent LH. Sarcoidosis and thrombocytopenia. Del Med J 1979; 56:341-5. PMID: 467750