In This Section

Kelly A. Whelan, PhD

Assistant Professor, Cancer and Cellular Biology
Assistant Professor, Fels Cancer Institute for Personalized Medicine

Kelly Whelan
For Patients
Contact Information

Contact Information


(215) 707-8467

About Me

Clinical Interests

  • Esophageal squamous cell carcinoma
  • Eosinophilic esophagitis
  • Gastroesophageal reflux disease
  • Barrett’s esophagus
  • Esophageal adenocarcinoma

Research Interests

Esophageal squamous epithelium exhibits a defined proliferation-differentiation equilibrium that supports barrier function, a primary defense against luminal contents, which may include food allergens and carcinogens. Esophageal pathology often features impaired squamous differentiation and barrier dysfunction, suggesting that mucosal defense mechanisms beyond mechanical barrier exist. We have identified autophagy as a critical cytoprotective mechanism in esophageal epithelia exposed to stressors relevant to esophageal squamous cell carcinoma (ESCC; one of the most deadly forms of human cancer), Eosinophilic Esophagitis (EoE; an emerging food allergy-associated inflammatory disorder) and Barrett’s Esophagus (BE; a precursor to esophageal adenocarcinoma). Using these studies as a foundation, we now aim to define the precise functional roles of autophagy in epithelial mucosal defense under conditions of health and disease. We utilize a multi-disciplinary approach coupling molecular biology and biochemical techniques with innovative murine disease models, 3D organoid culture and patient-derived specimens with associated clinical data to uncover fundamental mechanisms contributing to epithelial homeostasis and then apply this knowledge toward the development of novel translational avenues for prevention, prognosis and therapy in benign and malignant human diseases.

Education, Training & Credentials

Educational Background

  • Postdoc, University of Pennsylvania, Philadelphia, PA, 2015
  • PhD, Drexel University, Philadelphia, PA, 2011
  • BA, Rosemont College, Rosemont, PA, 2003

Honors & Awards

  • DDW 2017 Basic Science Travel Award, American Gastroenterological Society, 2017
  • NIDDK K01 Mentored Research Scientist Development Award, 2015-2020
  • National Institutes of Health Loan Repayment Program Award in Clinical Research, 2014-present
  • Ruth L. Kirschstein National Research Service Award for Individual Postdoctoral Fellows Recipient, 2013-2015

Digital Bibliography

View PubMed Publications