In This Section

Adil I. Khan, MSc, PhD

Medical Director, Point-of-Care Testing & Clinical Chemistry Laboratories, Temple University Health System
Professor, Pathology & Laboratory Medicine

Adil Khan
Contact Information

Contact Information




About Me

Research Interests

  • Role of adhesion molecules in leukocyte trafficking in health and disease
  • Role of extracellular vesicles in disease processes
  • Markers of inflammation
  • Point-of-care testing and laboratory instrumentation evaluations
  • Assay development / interference studies
Education, Training & Credentials

Educational Background

  • Fellowship, University of Texas Southwestern Medical Center at Dallas, 2006
  • PhD, The National Heart and Lung Institute at Imperial College School of Medicine, University of London, 2000
  • MSc, London School of Hygiene and Tropical Medicine, 1992

Honors & Awards

  • Clinical Pathology Faculty of the Year Award For Teaching, Temple University
  • American Association for Clinical Chemistry, Clinical Chemist Recognition Award
  • Chair, Committee on Point of Care Testing, International Federation of Clinical Chemistry and Laboratory Medicine
  • Chair, Philadelphia Section of American Association of Clinical Chemistry
  • Treasurer, Philadelphia Section of American Association of Clinical Chemistry
  • Ayub Medical College Award for contributions to Laboratory Medicine in Pakistan
  • Women Medical College Award for contributions to Laboratory Medicine in Pakistan
  • Islamic International Medical College Award for contributions to Laboratory Medicine in Pakistan.
  • Clinical Laboratory Standards Institute, USA, Member Document Development Committee


  1. Killeen A, Khan AI, Ladwig P, Burn N, Alter D, Budd JR, Caposino PV, Huang J, Kondratovich MV, Vaks JE, Varlan AR, Vesper HW, Xu C. Constructing and Interpreting an Error Grid for Quantitative Measurement Procedures. 2nd ed. CLSI guideline EP27-Ed2. June 2022.
  2. Padhiar NH, Liu JB, Wang X, Wang XL, Bodnar BH, Khan S, Wang P, Khan AI, Luo JJ, Hu WH, Ho WZ. Comparison of BNT162b2-, mRNA-1273- and Ad26.COV2.S-Elicited IgG and Neutralizing Titers against SARS-CoV-2 and Its Variants. Vaccines (Basel). 2022 May 27;10(6):858. doi: 10.3390/vaccines10060858. PMID: 35746466; PMCID: PMC9228110.
  3. Khan AI: POCT: a “win-win” scenario for all involved. April 7 2022.
  4. Liu J, Bodnar BH, Padhiar NH, Khan AI, Meng F, Saribas S, Wang P, Wang X, McCluskey E, Shah S, Zhao H, Luo JJ, Hu WH, Ho WZ. Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants. Clin Transl Med. 2021 Dec;11(12):e644. doi: 10.1002/ctm2.644. PMID: 34923762; PMCID: PMC8684769.
  5. Khan AI and Wu AH:. Point-of-Care Testing In: Self-Assessment Q&A in Clinical Laboratory Science. Elsevier, 2021.  ISBN: 9780128220931
  6. Liu J, Bodnar BH, Meng F, Khan AI, Wang X, Saribas S, Wang T, Lohani SC, Wang P, Wei Z, Luo J, Zhou L, Wu J, Luo G, Li Q, Hu W, Ho W. Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor. Cell Biosci. 2021 Aug 30;11(1):168. doi: 10.1186/s13578-021-00680-8. PMID: 34461999; PMCID: PMC8404181.
  7. Khan AI. Best Laboratory Practices Regarding POCT in Different Settings (Hospital and Outside the Hospital). EJIFCC. 2021 Jun 29;32(2):124-130. PMID: 34421480; PMCID: PMC8343050.
  8. Khan AI, Khan M, Tirimacco R. Catering for the Point-of-Care Testing Explosion. EJIFCC. 2021 Jun 29;32(2):244-254. PMID: 34421493; PMCID: PMC8343052.
  9. Xu XQ, Zhang B, Guo L, Liu Y, Meng FZ, Wang X, Hu WH, Khan AI, Ho WZ. Exosomes Transport Anti-Human Immunodeficiency Virus Factors from Human Cervical Epithelial Cells to Macrophages. J Innate Immun. 2021;13(5):269-279. doi: 10.1159/000514886. Epub 2021 Jun 3. PMID: 34082434; PMCID: PMC8460989.
  10. Khan AI. Transforming Clinical Pathways. Arch Pathol Lab Med. 2020 Oct 1;144(10):1164-1165. doi: 10.5858/arpa.2020-0438-ED. PMID: 33002150.
  11. Zucker ML, LaDuca FM, Khan AI, Owen R, Bennett SF, Clark S, Fantz CR, Halim AB, Kaur P, Kocis PT, Lessard C, Nevisn K, Riley PW, Stavelin A, Yu HYE;  POCT14-Ed2 : Point-of-Care Coagulation Testing and Anticoagulation Monitoring  (2nd Edition), CLSI, July, 2020.
  12. Khan AI: Point of Care Testing Compliance: How Partnering With Nursing Leadership and Sharing Data Upped Performance on a Crucial Parameter. Clinical Laboratory News, Jun 1, 2018.
  13. Mamone L, Jones J, Liu S, Li Y, Goldsmith B, Khan AI. Multiple Myeloma: The Case of the Disappearing Band. Lab Med. 2017 Dec 22;49(1):87-91. doi: 10.1093/labmed/lmx045. PMID: 29309675.
  14. Khan AI: Why is Being a Point-of-Care Coordinator a Blessing In Disguise? NACB Scientific Shorts, 2017, July 12.
  15. Malik A, Chakraborti B, Patel V, Khan AI: Comparison of the analytical and diagnostic performance of an automated immunoassay and liquid chromatography tandem mass spectrometry for 25-hydroxy vitamin D. ASCP 2016 Annual Meeting September 14-16, 2016 in Las Vegas, NV.
  16. Khan AI: Choosing the right point-of-care coordinator. MLO Med Lab Obs. 2017, 49(7):30. Choosing the right point-of-care coordinator | Medical Laboratory Observer (
  17. Khan AI, Jaman E, Kelly ML, Khan M, Khattak RU, Toles SM: Quality Assurance Activity Investigating the Effectiveness of POC Glucose Meters in Maintaining Tight Glycemic Control in an Urban Tertiary Teaching Hospital. Undergraduate Research Program Symposium, Temple University, Philadelphia USA. Sept. 17 2015
  18. Patel V, Qiu J, Wang J, Aneja A, Khan AI,  Ekpe JF, Szydlowska M, Goldsmith BM: Validation and Correlation study of the Values for the Beckman cTnI and TnI+3 Assay on the DxI 800 and Access-2 Analyzers. AACC July 29, 2015.
  19. Khan AI: Quality Requirements for Point of Care Testing when Traditional Systems Fail. In: Global Point of Care: Strategies for Disasters, Emergencies, and Public Health Resilience, Editors: GJ Kost & CM Curtis, AACC Press 2015.
  20. Grant ML, Hotchandan N, Khan AI, Goldsmith BM, Ekpe JF, Qiu J, Moolten DN, Li Y: Therapeutic Plasma Exchange for Hypertriglyceridemic Necrotizing Pancreatitis. American Society for Apheresis, May 6-9 2015.
  21. Qiu J, Luo X, Uthup M, Khan AI, Goldsmith BM: Validation Study for Nine Analytes in Non-Standard Body Fluids. ASCP 2015.
  22. Khan, AI. Using Glucose Meters in Hospital Environments: Some Challenges and Resolutions for Point-of-Care Testing. Point of Care: The Journal of Near-Patient Testing & Technology: September 2014 - Volume 13 - Issue 3 - p 97-100. doi: 10.1097/POC.0000000000000031.
  23. Viren P, Jihui Q, Jindong W, Khan AI, Ekpe JF, Szdlowska M, Goldsmith BM: Verifying A Cut-Off Value for the Beckman TnI+3 Assay on the DxI and Access Analyzers. AACC, 2014.
  24. Parajuli S, Bhattacharyya S, Hotchandani N, Khan AI, Goldsmith BM. Correlation of Automated Immunoassay (Abbott Architect i2000 SR) with Liquid Chromatography-Tandem Mass Spectrometry Method, USCAP, 2014.
  25. Jin M, Khan AI. Procalcitonin: Uses in the Clinical Laboratory for the Diagnosis of Sepsis, Laboratory Medicine, Volume 41, Issue 3, March 2010, Pages 173–177,
  26. Khan AI: POCT in Acute Coronary Syndromes: ADVANCE for Administrators of the Laboratory 2009, 18 (10) 44-46.
  27. Polson J, Wians FH., Jr., Orsulak P, Fuller D, Murray N, M. Koff J, Khan   AI, Balko JA, Hynan LS, ,Lee WM: False Positive Acetaminophen Levels in Patients with Liver Injury: Clin Chim Acta 2008, 391(1-2):24-30). ISSN 0009-8981, (
  28. Khan AI: More POCT on CBG: MLO Med Lab Obs. 2007 39(11):6
  29. Reddy V, Khan AI, Remaley A, Wians Jr. FH: An update on Point-of-Surgery Testing. Lab Med 2006, 37(12): 754-756.
  30. Khan AI, Cimo M, Hashim IA, Wians Jr. FH: Hyperammonemia in a 20-year old women: Lab Med 2006, 37 (4): 226-228.
  31. han AI, Vasquez V, Gray J, Wians Jr. FH, Kroll MH: Variability of Results Between Point-of-Care Testing Glucose meters and Central Laboratory Analyzer. Arch Pathol Lab Med 2006, 130:10:1527-32. doi: 10.5858/2006-130-1527-TVORBP. PMID: 17090196.
  32. Khan AI, Susa J, Ansari MQ: Systemic sclerosis (scleroderma). Lab Med 2005, 36(11) 723-726.
  33. Khan AI, Vasquez V, Gray J, Kroll MH: Investigating the reliability of POCT glucose meters. Clin Chem 2005, 51(6) A252.
  34. Khan AI, Heit B, Andonegui G, Colarusso P and Kubes P: Lipo-polysaccharide: a p38 MAPK-dependent disrupter of neutrophil chemotaxis. Microcirculation 2005, 12 (5):421-32.
  35. Khan AI, Kerfoot SM, Heit B, Liu L, Andonegui G, Rufell B, Johnson P, and Kubes P: Role for CD44 and hyaluronan in neutrophil recruitment. J Immunol 2004, 173 (12): 7594-601. doi: 10.4049/jimmunol.173.12.7594. PMID: 15585887.
  36. Khan AI: Lab methods/instruments: Then and now – IEP versus IFE. Lab Med 2004, 35 (11) 662-663.
  37. Khan AI, Kubes P: Role of CD44 in neutrophil recruitment in MIP-2 induced acute inflammation. FASEB Journal 2003, Mar 17 Part 2 Suppl. S, 17 (5): A1365-A1365.
  38. Venturi GM, Tu LL, Kadono T, Khan AI, Fujimoto Y, Oshel P, Block CB, Miller AS, Albrecht RM, Kubes P, Steeber DA, Tedder TA: Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity 2003, 19 (5): 713-724. doi: 10.1016/s1074-7613(03)00295-4. PMID: 14614858.
  39. Venturi GM, Tu LL, Kadono T, Khan AI, Fujimoto Y, Bock CB, Miller AS, Kubes P, Steeber DA, Tedder TF: L-selectin endoproteolytic release controls leukocyte interactions with vascular endothelial cells by regulating cell surface receptor density. FASEB Journal 2003, Apr 14 Suppl. S, 17 (7): C285-C285.
  40. Kubes P, Heit B, van Marle G, Johnston JB, Knight D, Khan A, and Power C: In vivo impairment of neutrophil recruitment during lentivirus infection. J Immunol 2003 171: 4801-4808. doi: 10.4049/jimmunol.171.9.4801. PMID: 14568958.
  41. Khan AI, Landis RC, Malhotra R: L-selectin ligands in lymphocyte re-circulation and models of inflammation. Inflammation 2003, 27 (5): 265-280. doi: 10.1023/a:1026056525755. PMID: 14635784.
  42. Khan AI, Landis RC, Malhotra R, Haskard DO: Identification and characterization of L-selectin ligands in porcine inguinal lymphoid tissues. Immunology 2002, 105(4): 441-9. doi: 10.1046/j.1365-2567.2002.01393.x. PMID: 11985664; PMCID: PMC1782687.
  43. Khan AI, Landis RC, Malhotra R, Haskard DO: Identification of an L-selectin ligand in peripheral lymph node conditioned medium, 9th UK Adhesion Meeting 1999, University of Birmingham, UK.
  44. Khan AI, Landis RC, Mahiouz DL, Haskard DO: Identification of L-selectin ligands with mAb MECA 79 and L-selectin-Fc chimeras 6th UK Adhesion Meeting 1998 ICRF, UK.
  45. Mahmood N, Piacente S, Burke A, Khan A, Pizza C: Constituents of Cuscuta reflexa are anti-HIV agents. Antiviral chemistry & chemotherapy 1997, 8 (1): 70-74. DOI:10.1177/095632029700800108
  46. Mahmood N, Piacente S, Pizza C, Burke A, Khan AI, Hay AJ: The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena, Biochem Biophys Res Commun 1996, 229: 73-79. doi: 10.1006/bbrc.1996.1759. PMID: 8954085.
  47. Arouma OI, Spenser JP, Halliwal B, Willie HJ, Aeschbach R, Khan A, Mahmood N: Antioxidant and antiviral actions of Herbor and Spice Provencal herbs. Food & Chem Toxicology 1996, 34: 449-56. doi: 10.1016/0278-6915(96)00004-x. PMID: 8655093.
  48. Gardiner JM, Loyns CR, Burke A, Khan A, Mahmood N: Novel benzimidazole N-alkoxides and evaluation against HIV-1 and RT, Conf. Proc. 9th Annual AIDS workshop, UMIST, Manchester, 4-6 Sept. 1995, pp.64.
  49. Gardiner JM, Loyns CR, Burke A, Khan A, Mahmood N: Synthesis and HIV-1 inhibition of novel benzimidazole derivatives. Bioorganic and Medicinal Chemistry Letters 1995,12:1251-1254. DOI:10.1016/0960-894X(95)00203-6
  50. Mahmood N, Burke A, Khan A, Chambers P, Ramadas SR, Sabina J, Hay A: Anti-HIV activity in chronically infected H9 and acutely infected C8166 cells by macrocyclic amides, Conf.Proc. 9th Annual AIDS workshop, UMIST, Manchester, 4-6 Sept. 1995, pp.64.
  51. Mahmood N, Burke A, Khan A, Chambers P, Hay A: An ELISA method for the demonstration of CD4/gp120 interactions, Conf.Proc. 8th Annual AIDS workshop, UMIST, Manchester, 4-7 Sept 1994, pp.95.
  52. Houghton PJ, Woldemariam TZ, Khan AI, Burke A, Hay A, Mahmood N: Antiviral activity of natural and semi-synthetic Chromone alkaloids, Antiviral Research 1994, 25: 235-244.