In This Section

Pooja Jadiya, PhD

Instructor, Center for Translational Medicine

Pooja Jadiya
Contact Information

Contact Information

Phone

215-707-9144

Email

poojajadiya@temple.edu
About Me

Research Interests

Alzheimer’s disease (AD) is characterized by the loss of memory accompanied by neuronal cell death and metabolic dysfunction. Numerous studies have reported an increase in neuronal intracellular calcium (iCa2+) signaling as an early event in AD pathogenesis. It is postulated that a prolonged elevation in neuronal iCa2+ promotes excessive mitochondrial calcium (mCa2+) uptake, yet to date, no study has examined the contribution of mCa2+ flux to disease progression. Since mCa2+ flux is an important regulator of cellular respiration and cell death, both of which are involved in AD pathogenesis, we hypothesize that mCa2+ dysregulation is a key contributor to AD pathology and may contribute to metabolic deficits and neuronal demise.

Ca2+ enters the mitochondrial matrix via the mitochondrial calcium uniporter channel (mtCU). Recently, genetic components of the mtCU have been identified including MCU, MCUB, MCUR1, EMRE, MICU1, MICU2, and MICU3. mCa2+ efflux is primarily occurred by NCLX (mitochondrial Na+/Ca2+ exchanger). The overarching aim of current research is to dissect how specifically mCa2+ dysregulation contributes to AD pathogenesis. We are generating/utilizing various neuronal-specific knockouts and overexpression of mtCU components to manipulate the mCa2+ flux in AD mutant mouse models. We aim to discover new therapeutic targets for AD and associated mitochondrial dysfunction.

For more information, visit https://sites.google.com/site/poojajadia/home

Education, Training & Credentials

Educational Background

  • Fellowship, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA
  • Fellowship, Waksman Institute of Microbiology, Rutgers University, Piscataway, NJ
  • PhD, Biological Sciences, CSIR-Central Drug Research Institute, Lucknow, India
  • MSc, Biotechnology, Dr. H.S. Gour University, Sagar, India

Memberships

  • American Society for Cell Biology (ASCB)
  • Society for Neuroscience (SfN)
  • The New York Academy of Sciences (NYAS)
  • Society for Mitochondrial Research and Medicine

Honors & Awards

  • K99/R00: Pathway to Independence Award, NIH-National Institute on Aging, 2020
  • Keystone Symposia Future of Science Fund Scholarship on Neurodegeneration, Keystone Symposia on Molecular and Cellular Biology, 2020
  • F1000 Outstanding Presentation Award, New York Academy of Sciences, 2018
  • The Eliot Stellar Best Scientific Presentation Award, Annual Meeting of the Philadelphia Chapter of the Society for Neuroscience (PCSfN), 2018
  • Best Presentation Award, Mid-Atlantic Pharmacology Society (MAPS) Symposium, 2017
  • CPOW (Committee for Professional Opportunities for Women) travel Award, Biophysical Society Annual Meeting, 2017
  • Best Scientific Presentation Award, 6th Regional Translational Research in Mitochondrial, Aging, and Disease (TriMAD) Symposium, 2016
  • Best Scientific Presentation award, 4th Annual Temple translational science symposium, 2016
  • Charles and Johanna Busch Postdoctoral Fellowship, The Charles and Johanna Busch Biomedical Fund, USA, 2015
  • Lindau Nobel Laureate Meeting Fellowship from the Department of Science and Technology (DST)- India and the German Research Foundation (DFG)- Germany, 2014
  • Dr. JM Khanna Memorial Early Career Achievement Award, CSIR-Central Drug Research Institute, India, 2014
  • International Travel Fellowship Award, Department of Science and Technology, International Co-operation in Science, India, 2013
  • Best Scientific Presentation award, Lucknow Science Congress, India, 2013
  • AcSIR-Ph.D Research Fellowship, Council of Scientific and Industrial Research (CSIR), India, 2012
  • Senior Research Fellowship, Council of Scientific and Industrial Research (CSIR), India, 2012
Publications

Digital Bibliography

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