In This Section

Developmental Core

This core provides an organization and structure that will effectively integrate mentorship and new project development with the utilization of the other cores to achieve the objectives of the Comprehensive NeuroAIDS Center (CNAC). This core provides financial support for novel and innovative studies that take the field of NeuroAIDS in new directions, in studies ranging from basic to translational/clinical studies. Through the letter of intent and application process, applicants are provided mentorship and guidance via interaction with relevant CNAC members and/or Core leaders in order to foster successful project and career development. While this mechanism of support is primarily designed for junior faculty, we encourage application from clinicians who would like to develop research programs, potentially in collaboration with a basic scientist, or from more senior researchers wishing to pursue novel research directions.

Leadership

Jay Rappaport, PhD
Developmental Core Leader
Department of Neuroscience
3500 N. Broad Street
Room 746, MERB
Philadelphia, PA 19140
215-707-6248
jayrapp@temple.edu
 

Since inception, the Developmental Core has funded 10 individual projects over two years:

2014

  • “Eradication of JCV using a new class of genome engineering tool, RNA-guided CAs9 cleavage” – Hassen Wollebo, PhD, Assistant Scientist, Department of Neuroscience, Temple University
  • “Assessment of Hearing and Evaluation of Site of Pathology in Mouse Models of HIV” – Pamela Roehm, MD, PhD, Associate Professor, Department of Neuroscience; Associate Professor, Otolaryngology - Head and Neck Surgery

2013

  • “Metabolomics of macrophages overexpressing HIV-1 Vpr protein: A targeted Approach” – Carlos Barrero, MD, Associate Scientist, Biochemistry Department, Lewis Katz School of Medicine at Temple University
  • “Transcriptomic Effects of Cannabinoids on HIV-1 Replication” – Mario Chin, PhD, Assistant Professor, Department of Microbiology and Immunology, Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University
  • “Role of microbial translocation in altered plasma environment and CD16+ monocyte expansion in HIV” – Tracy Fischer-Smith, PhD, Assistant Professor, Department of Neuroscience, Lewis Katz School of Medicine at Temple University
  • “Interplay between microRNAs and HIV-1 in human microglia and astrocytes” – Julio Martin-Garcia, PhD, Associate Professor, Department of Microbiology and Immunology, Drexel University College of Medicine
  • “The relationship between resting state functional connectivity and neurocognitive function in HIV infected subjects: a pre and post cART perspective” – Erin O’Connor, MD, Associate Professor, Department of Radiology, Lewis Katz School of Medicine at Temple University

2012

  • “Role of Exosomes in NeuroAIDS” – Prasun Datta, PhD, Assistant Professor, Department of Neuroscience, Lewis Katz School of Medicine at Temple University
  • “Impact of HIV-1 Tat genetic variants on the blood-brain barrier” – Michael Nonnemacher, PhD, Assistant Professor, Department of Microbiology and Immunology, Drexel University College of Medicine
  • “Evaluating the efficacy of the Virtual Reality Supermarket task for predicting neurocognitive function in HIV-infected subjects” – Giuseppe Russo, PhD, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University