In This Section

Jian Huang, MD, PhD

Assistant Professor, Pathology and Laboratory Medicine
Assistant Professor, Center for Metabolic Disease Research

Jian  Huang
For Patients
Contact Information

Contact Information

Phone

215-707-2647

Email

jianh@temple.edu
About Me

Research Interests

Dr. Huang’s laboratory studies hematopoietic stem cells (HSCs) self-renewal and differentiation regulatory mechanisms as well as leukemia. Specifically, research has focused on three main topics: 1. Understanding the roles of GSK3 and Wnt signaling in the regulation of HSCs self-renewal, and the contribution of Wnt signaling to leukemogenesis; 2. Investigating the role of epigenetic regulation especially DNA methylation in HSCs function; 3. Identifying new targets in leukemia therapy with a multiplexed genome editing CRISPR screening platform.

We use both transgenic and humanized NSG model as the major research system. The knowledge gained from these studies will provide new insights into the mechanisms of the regulation of HSCs self-renewal and differentiation, as well as the molecular and cellular biology of leukemia stem cells. It will be valuable for the diagnosis and prevention of hematopoietic diseases and the development of innovative therapeutics for many hematopoietic disorders.

Education, Training & Credentials

Educational Background

  • PhD, Molecular Biology, State University of New York, Downstate Medical Center, Brooklyn, NY, 2005
  • MD, Peking University Health Sciences Center, Bejing, China, 1997
  • BA, Peking University Health Sciences Center, Bejing, China, 1995
Publications

PubMed Publications

View PubMed Publications

Hou P, Chen S, Wang S, Yu X, Chen Y, Jiang M, Zhuang K, Ho W, Hou W, Huang J, Guo D. (2015) Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. Scientific Reports. Sci Rep. 2015 Oct 20;5:15577.

Nelson J, Wu Yi, Jiang XH, Berretta R, Houser S,  Choi E, Wang JF,  Huang J, Yang XF,  and Wang H. Hyperhomocysteinemia suppresses BM CD34+/VEGFR2+ cells and inhibits progenitor cell mobilization and homing to injured vasculature - A role of β1 integrin in progenitor cell migration and adhesion. FASEB J. FASEB J. 2015 Apr 8. pii: fj.14-267989.

Liu X, Niu Y, Yuan H, Huang J, Fu L (2015) AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy. Metabolism 2015, Jan 31... Expand