Jian Huang, MD, PhD
Assistant Professor, Pathology and Laboratory Medicine
Assistant Professor, Center for Metabolic Disease Research
- Contact Information
- About Me
Dr. Huang’s laboratory studies hematopoietic stem cells (HSCs) self-renewal and differentiation regulatory mechanisms as well as leukemia. Specifically, research has focused on three main topics: 1. Understanding the roles of GSK3 and Wnt signaling in the regulation of HSCs self-renewal, and the contribution of Wnt signaling to leukemogenesis; 2. Investigating the role of epigenetic regulation especially DNA methylation in HSCs function; 3. Identifying new targets in leukemia therapy with a multiplexed genome editing CRISPR screening platform.
We use both transgenic and humanized NSG model as the major research system. The knowledge gained from these studies will provide new insights into the mechanisms of the regulation of HSCs self-renewal and differentiation, as well as the molecular and cellular biology of leukemia stem cells. It will be valuable for the diagnosis and prevention of hematopoietic diseases and the development of innovative therapeutics for many hematopoietic disorders.
- Education, Training & Credentials
- PhD, Molecular Biology, State University of New York, Downstate Medical Center, Brooklyn, NY, 2005
- MD, Peking University Health Sciences Center, Bejing, China, 1997
- BA, Peking University Health Sciences Center, Bejing, China, 1995
Land RH, Rayne AK, Vanderbeck AN, Barlowe TS, Manjunath S, Gross M, Eiger S, Klein PS, Cunningham NR, Huang J, Emerson SG, Punt JA (2015) The Orphan Nuclear Receptor NR4A1 Specifies a Distinct Subpopulation of Quiescent Myeloid-Biased Long-Term HSCs. Stem Cells 33:1(278-88)Valvezan AJ, Huang J, Lengner CJ, Pack M, Klein P.S. (2014) Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1). Dis Model Mech 7:1 (63-71).
Yang Q, Monticelli LA, Saenz SA, Chi AW, Sonnenberg GF, Tang J, De Obaldia ME, Bailis W, Bryson JL, Toscano K, Huang J, Haczku A, Pear WS, Artis D, Bhandoola A (2013) T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 38(4): 694-704.
Huang J, Nguyen-McCarty M., Hexner E.O, Danet-Desnoyers G.A., and Klein P.S. (2012) Maintenance and Expansion of Hematopoietic Stem Cells through regulation of Wnt and mTOR Pathways. Nature Medicine. 18(12), 1778-85.
O’Brien WT, Huang J, Buccafusca R, Garskof J, Valvezan AJ, Berry GT, and Klein P.S. (2011) Essential role of glycogen synthase kinase-3 in ß-arrestin-2 complex formation and lithium-sensitive behaviors in mice. J Clin Invest. 121(9), 3756–62.
Huang J, Zhang Y., Bersenev A., O’Brien W.T, Tong W., Emerson S.G, Klein P.S. (2009) Pivotal Role for Gsk3 in Hematopoietic Stem Cell Homeostasis. J Clin Invest. 119(12), 3519-29.
Schloesser RJ *, Huang J *, Klein P.S, Manji H.K. (2008) Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology. 33(1), 110-33. (* These authors contribute equally to this work)
Huang J, Laing B., Qiu J., and Laurent B.C. (2005) ATP-Dependent Chromatin-Remodeling complexes in DNA Double-Strand Break Repair-Remodeling, Pairing and (Re) pairing. Cell Cycle. 4(12), 1713-1715.
Chai B. *, Huang J*, Cairns B.R, and Laurent B.C. (2005) Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair. Genes & Development. 19, 1656-1661.
(* These authors contribute equally to this work)
Huang J, Hsu J.M., and Laurent B.C. (2004). The RSC nucleosome-remodeling complex is required for cohesin’s association with chromosome arms. Molecular Cell. 13, 739-750.
Huang J, and Laurent B.C. (2004). A role for the RSC chromatin remodeler in regulating cohesion of sister chromatid arms. Cell Cycle. 3(8), 973-975.
Hsu J.M., Huang J, Meluh P.B., and Laurent B.C. (2003). The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol. Cell. Biol. 23, 3202-3215. Collapse