In This Section

Jessica Pfleger, PhD

Instructor (Research), Center for Translational Medicine

Jessica Pfleger
About Me

Research Interests

The main focus of our research is to understand the underlying molecular mechanisms of cardiovascular disease. Specifically, our focus is on the metabolic perturbations that occur in response to, as well as drive, cardiac pathology, such as insulin resistance. Current projects in the lab address the transcriptional and posttranscriptional regulation of genes involved in cardiac dysfunction. This includes epigenetic regulation, such as transcription factor binding and histone modification. Recently, for example, we have begun to dissect the role of transcription factor, forkhead box protein (Fox)O1 in the regulation of genes involved in isoproterenol- or transverse aortic constriction (TAC)-induced hypertrophy and insulin resistance. Other projects focus on the discovery and characterization of novel molecules involved in metabolic regulation in cardiac pathology. It is our objective to understand the intricate biology of the heart for the development of innovative and effective therapies for disease.

Education, Training & Credentials

Educational Background

  • Postdoctoral Fellowship, Laboratory of Dr. Walter Koch, Temple University, Philadelphia, PA
  • PhD, Cellular Biology and Molecular Medicine, Rutgers University - NJMS, Newark, NJ

Memberships

  • Basic Cardiovascular Sciences Council, American Heart Association
  • International Society for Heart Research
Publications

Digital Bibliography

View Digital Bibliography