In This Section

Dhanendra Tomar, PhD

Instructor (Research), Center for Translational Medicine

Dhanendra Tomar
Contact Information

Contact Information

Phone

215-707-9144

Email

dhtomar@temple.edu
About Me

Research Interests

Mitochondria are multivariate signal processors of cytoplasmic calcium flux. Mitochondrial calcium participates in cellular energy production through the regulation of bioenergetics yet can also promote different modes of cell death. Calcium also involved in the regulation of mitochondrial trafficking, structural homeostasis, and dynamics. Dysregulation of mitochondrial calcium flux has been linked to numerous cellular dysfunctions, including chronic oxidative burden, autophagy, and sensitization for cell death, which are the central hallmarks of the multiple pathologies. High cytoplasmic calcium facilitates mitochondrial calcium accumulation through the mitochondrial calcium uniporter (mtCU), a multiprotein complex present on the inner mitochondrial membrane. Mitochondrial matrix calcium homeostasis is achieved through the NCLX mediated calcium efflux. Accumulation of calcium in mitochondria leads to the opening of mitochondrial permeability transition pore (MPTP) that results in the matrix solutes leakage, solvent flux to the matrix, subsequent mitochondrial swelling, and the onset of necrotic cell death. The calcium-sensing plays a crucial role in these cellular events.

The MICUs in the mitochondria and MIROs on the mitochondrial surface sense the calcium through the EF-hand domains, resulting in the regulation of mitochondrial functions, and dynamics. The protein post-translational modifications and the protein turnover are the critical determinants of the protein functions. Our current research focuses on the identification of new regulators and regulatory events associated with the mitochondrial calcium sensing and flux, using the protein biochemistry, and high-end imaging-based approaches. We aim to characterize the pathophysiological consequences of these signaling events using the mouse genetics and physiology based in vivo methods. Identifying the interactions between protein post-translational modifications, turnover, and mitochondrial calcium-sensing/flux system could lead to novel therapeutic approaches to treat the associated pathologies.

For more information, visit www.mitobiolab.org

Education, Training & Credentials

Educational Background

  • Postdoctoral fellowship, Center for Translation Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
  • PhD, Biotechnology, Savitribai Phule Pune, India
  • MS, Microbiology, Gurukul Kangri University, India

Memberships

  • American Society for Cell Biology (ASCB), USA
  • American Heart Association, USA
  • The New York Academy of Sciences (NYAS), USA
  • South Asian Heart Association (SAHA), USA
  • Society for Mitochondrial Research and Medicine, India

Honors & Awards

  • Best Scientific Poster award at Basic Cardiovascular Sciences Scientific Sessions, Boston, USA, 2019
  • Young Investigator Award from South Asian Heart Association (SAHA), USA, 2019
  • Accomplishing Career Transitions (ACT) Fellow, American Society of Cell Biology, 2019
  • Career Development Award, American Heart Association, 2019
  • BCVS New Investigator Travel Award, American Heart Association, 2018
  • Research Excellence Award, American Heart Association, 2017
  • Postdoctoral Fellowship, American Heart Association, 2017
  • Best Presentation Award, NHLBI/NIDDK Mitochondrial Biology Symposium, 2016
  • Humboldt Fellowship for Postdoctoral Researchers, Alexander von Humboldt Foundation, Germany, 2014
  • Raman-Charpak Visiting Fellowship, Indo-French Centre for the Promotion of Advanced Research (CEFIPRA), 2013
  • Prof. A. R. Rao Young Researcher Award, Society for Mitochondrial Research and Medicine-India, 2012
  • Best Presentation Award, International Symposium on Cancer Biology, National Institute of Immunology, India, 2011
  • Junior/Senior Research Fellowship, Council of Scientific & Industrial Research (CSIR), India, 2008
Publications

Digital Bibliography

View Digital Bibliography