Elisabetta Liverani, PhD
Instructor, Sol Sherry Thrombosis Research Center
- Contact Information
- About Me
It has become clearer that platelets play a critical role during inflammation, in particular they appear to orchestrate the response of other cells of the immune system and more specifically neutrophils, through both secretion and cell-cell interaction. I am very interested in understanding platelet activation and their interaction with other immune cells during inflammation.
During the past years, we investigated the role of the G protein-coupled receptor P2Y12 in mediating the ADP-stimulated activation of platelets during LPS-induced inflammation and sepsis (cecal ligation and double puncture (CLP)). Our results have indicated that P2Y12 receptor deficiency and antagonism modulated systemic inflammation and lung injury. Hence activated platelets play a central role during inflammation that is dependent on P2Y12 receptor activation.
My current research focus on further investigating platelet functions and platelet-neutrophil-endothelial cells interactions during inflammation in vivo, and during inflammatory conditions in vitro.
- Education, Training & Credentials
- PhD, Pharmacology, University of the West of England, Bristol, UK, 2007
- BSc, Biological Sciences, University of Bologna, Bologna, Italy, 2001
- American Heart Association
- Mid-Atlantic Pharmacology Society
- Society of Leukocyte Biology
- North American Society on Thrombosis and Hemostasis
Liverani E and Paul C. Adrenomedullin and Glucocorticoids Interaction at the glial/endothelial interface: two sides of the same regulatory coin? Receptor and Clinical Investigation 2014 1: 1-3. doi: 10.14800/rci.25
Liverani E., Kilpatrick L. and Kunapuli S.P. P2Y12 receptor in cardiovascular diseases Mini-Review Journal of Cardiovascular Disease 2014 2(4): 203-208