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Xiongwen Chen, PhD

Associate Professor, Physiology
Associate Professor, Cardiovascular Research Center
Associate Professor, Center for Metabolic Disease Research

Xiongwen Chen
Contact Information

Contact Information







MERB 1045B
About Me

Research Interests

1- Ca2+ regulation of gene expression, mitochondria and energy production, protein synthesis and degradation, molecular trafficking and localization, myocyte proliferation and maturation in normal and diseased hearts. 2- The role of smooth muscle cell Ca2+ signaling in hypertension and atherosclerosis. We are using a transgenic mouse model with increased Ca2+ influx into smooth muscle cells for this study. 3- The roles of EPAC and PKI/PKA in heart disease development: we are trying to unveil novel aspects of cAMP signaling by studying the balances between EPAC and PKA, and between PKI and PKA, in cardiac physiology and pathology. Based on the mechanistic study, we will perform translational studies using AAV vectors to overexpress PKI in stressed hearts to ameliorate heart disease development.

Education, Training & Credentials

Educational Background

  • PhD, Lewis Katz School of Medicine at Temple University, 2003
  • MS, Agricultural University, Beijing, China, 1997
  • Undergraduate degree, Agricultural University, Beijing, China, 1994


  • Biophysical Society
  • American Heart Association
  • Heart Failure Society of America
  • Leadership Committee, Basic Science Council, American Heart Association

PubMed Publications

View PubMed Publications