Won Han, MD
Associate Professor, Clinical Medicine
- Contact Information
- About Me
- Acute kidney injury
- ANCA-associated vasculitis
- Non-invasive biomarker for acute renal failure
- Chronic kidney disease
- Renal cell carcinoma
- Education, Training & Credentials
- Clinical and Research Fellowship, Nephrology, Massachusetts General Hospital, Boston, MA, 2002
- Residency, Internal Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA, 1997
- MD, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 1994
- BA, Biology, University of Pennsylvania, Philadelphia, PA, 1988
- Internal Medicine
- Fellow, American Society of Nephrology
Han WK, Sapirstein A, Hung CC, Alessandrini A, Bonventre JV. Cross talk between cPLA2 and sPLA2 in hydrogen peroxide-induced arachidonic acid release in murine mesangial cell. sPLA2 regulates cPLA2 activity which is responsible for arachidonic acid release. JBC 2003, 278:24153-24163.
Han WK and Bonventre JV. Biological markers for the early detection of acute kidney injury. Current Opinion in Critical Care 2004, 10:476-482.
Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, Thadhani R, Bonventre JV. Human Kidney Injury Molecule-1 (hKIM-1) is a tissue and urinary tumor marker of Renal Cell Carcinoma. J Am Soc Nephrol 2005, 16:1126-1134.
Ye B, Skates S, Mok SC, Horick NK, Rosenberg HF, Vitonis A, Edwards D, Sluss P,
Han WK, Berkowitz RS, Cramer DW. Proteomic-Based Discovery and Characterization of Glycosylated Eosinophil-Derived Neurotoxin and COOH-Terminal Osteopontin Fragments for Ovarian Cancer in Urine. Clin Cancer Res 2006, 12: 432-441.
Balestrieri B, Hsu VW, Gilbert H, Leslie CC, Han WK, Bonventre JV, Arm JP. Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis. JBC 2006, 281:6691-6698.
Liangos O, Perianayagam MC, Vaidya VS, Han WK, Wald R, Tighiouart H, Mackinnon RW, Li L, Balakrishnan VS, Pereira BJ, Bonventre JV, Jaber BL. Urinary N-Acetyl-beta-(D)-Glucosaminidase Activity and Kidney Injury Molecule-1 Level Are Associated with Adverse Outcomes in Acute Renal Failure. J Am Soc Nephrol. 2007, 18: 904-912.
Lin F, Zhang PL, Yang XJ, Shi J, Blasick T, Han WK, Wang HL, Shen SS, Teh BT, Bonventre JV. Human Kidney Injury Molecule-1 (hKIM-1): A Useful Immunohistochemical Marker for Diagnosing Renal Cell Carcinoma and Ovarian Clear Cell Carcinoma. Am J Surg Pathol, 2007 31: 371-381.
Zhang PL, Rothblum LI, Han WK, Blasick TM, Potdar S, Bonventre JV. Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury. KI 2008, 73:608-614
Han WK, Waikar SS, Johnson A, Betensky RA, Dent CL, Devarajan P, Bonventre JV. Urinary biomarkers in the early diagnosis of acute kidney injury. KI 2008, 73:863-869.
Han WK, Wagener G, Zhu Y, Wang S, Lee HT. Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol 2009, 4:873-882.
Liangos O, Tighiouart H, Perianayagam MC, Kolyada A, Han WK, Wald R, Bonventre JV, Jaber BL. Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass. Biomarkers 2009, 14:423-431.
Hall IE, Yarlagadda SG, Coca SG, Zhu Wang Z, Doshi M, Devarajan P, Han WK, Marcus R, Parikh CR. Novel urinary biomarkers predict graft recovery and the need for dialysis after kidney transplantation. J Am Soc Nephrol 2010, 21:189-97.
Fontanilla F and Han WK. Kidney Injury Molecule-1 (KIM-1) as an early detection tool for acute kidney injury and other kidney diseases. Expert Opin Med Diagn 2011, 5:161-173
Hall IE, Coca SG, Perazella MA, Eko UU, Luciano RL, Peter PR, Han WK, Parikh CR. Risk of poor outcomes with novel and traditional biomarkers at clinical AKI diagnosis. Clin J Am Soc Nephrol 2011, 6:2740-2749.
Han WK. Biomarkers for early detection of acute kidney injury. Current Biomarker Findings. 2012, 2:77-85. Collapse