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Stephen Pilder, PhD

Associate Professor, Anatomy and Cell Biology
Assistant Professor, Fels Cancer Institute for Personalized Medicine

Stephen Pilder
Contact Information

Contact Information



About Me

Research Interests

Stephen H. Pilder, Ph.D., Associate Professor in the Department of Anatomy and Cell Biology, is a reproductive biologist with training and experience in cellular, genetic, and molecular approaches to the study of mammalian spermiogenesis, sperm motility, and sperm-egg interactions. His research focuses on the molecular and physiological bases of mammalian sperm function in the fertilization process, with primary emphasis on mammalian sperm motility. Infertility is a major cause of social, psychological, and economic stress throughout the developed world. Because increased research efforts into the genetic and molecular bases of male infertility hold promise for the development of advanced diagnostic tools and effective, less physically intrusive, and less expensive assisted reproductive therapies, this research is strongly supported by the National Institutes of Health. Dr. Pilder’s laboratory has engineered and presently utilizes numerous mouse models of male infertility that provide the material for isolating and studying the networks of genes responsible for numerous male infertility phenotypes. Recently, he and members of his laboratory have identified and isolated a tightly-linked complex of genes that operate in several signaling pathways to control unrelated calcium-dependent aspects of sperm function, such as hyperactivated motility, zona pellucida binding, and penetration of the egg plasma membrane. Dr. Pilder’s lab is currently characterizing these genes and the pathways in which they act. These studies are expected to provide insights into the coordinated regulation of mammalian sperm function and the basic molecular mechanisms underlying male fertility.

Education, Training & Credentials

Educational Background

  • Postdoctoral Fellowship, Molecular Genetics of the t Complex-Specific Hybrid Sterility, Princeton University, Princeton, NJ, 1991
  • Postdoctoral Fellowship,  Molecular Biology of the t Complex-SpecificTcp10 Multigene Family in Mice and Humans, Princeton University, Princeton, NJ, 1989
  • PhD, Molecular Biology, Princeton University, Princeton, NJ, 1986
  • BA, Philosophy, University of Cincinnati, Cincinnati, OH, 1970

Digital Bibliography

View PubMed Publications