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Shan He, PhD

Assistant Professor, Fels Institute for Cancer Research and Molecular Biology

Shan He
Contact Information

Contact Information



About Me

Research Interests

T-cell immune response is important for protecting the host from infections and tumors, but it also causes inflammatory disorders, such as autoimmune diseases and rejection of allogeneic grafts. Existing methods lack efficacy to control T cell-mediated disorders. My research involves investigating the cellular and molecular mechanisms of T cell-mediated alloimmunity and anti-tumor immunity. One emphasis is on defining the role of epigenetic regulator Ezh2 (a histone methyltransferase and the key component of polycomb repressive complex 2) in T cell activation, proliferation, differentiation and responses. The goal of the research is to develop Ezh2-based approach to improve the efficacy of T cell immunotherapy.

Education, Training & Credentials

Educational Background

  • Research Investigator, The University of Michigan, 2014
  • Postdoctoral Fellowship, The University of Michigan, 2013
  • PhD, Cell Biology, Chinese Academy of Sciences, 2009
  • BSc, Biological Technology, China Pharmaceutical University, 2003

PubMed Publications

View PubMed Publications