Suresh Verma, PhD
Assistant Professor, Center for Translational Medicine
- Contact Information
- About Me
The current focus of my laboratory is to understand the mechanisms that regulate pathological remodeling in the failing heart. As early inflammation and late fibrosis are major hallmarks for cardiovascular pathology, investigating the biological interaction between inflammation and fibrotic signaling pathways and identification of downstream signaling targets might serve as potential prophylaxis and treatment options for patients with cardiovascular diseases. In this direction, my lab is currently involved in the following projects: (1) Identify the stem/progenitor cells populations that are mainly involved in pathological cardiac fibrosis. We are anticipating that modulating the function of these progenitors will be promising step to cure cardiovascular diseases. (2) Additionally, contribution of endothelial cells in pathological fibrosis by endothelial to mesenchymal transition, under the influence of TGF-β2 signaling is a novel area of study to address unknown mechanisms in pathological remodeling. Identifying the molecular signaling components especially the wnt and Notch-1 signaling mechanisms will be a powerful strategy to reduce pathological fibrosis.
In addition to these two main projects, I am involved in related projects that studies cardiac autophagy in the heart. Previous we have shown that IL-10 therapy in heart showed strong anti-apoptotic effect, however, the signaling mechanism is not well known. Apoptosis and autophagy show strong association during heart failure. In this project, we ask whether persistent mechanical force on heart, during heart failure, induces pathological autophagy that leads to cardiac myocytes death; and whether regulation of this pathological autophagy could be a promising strategy to prevent heart failure.
My laboratory uses state of the art techniques and strategies such as genetically manipulated animal models, RNA interference, microRNA strategies, recombinant DNA technologies, Electron/Fluorescent microscopy etc to dissect out the mechanisms proposed above. Talented graduate students who are willing to perform these novel studies are welcome in our laboratory.
- Education, Training & Credentials
- Fellowship, Anti-inflammatory Therapy for Treatment of Heart Failure, Laboratory of Professor Raj Kishore, Feinberg Cardiovascular Research Institute, Chicago, Illinois, 2012
- Fellowship, Mechanical Signaling in Heart, Laboratory of Professor David E Dostal, Cardiovascular Research Institute, Temple, Texas, 2009
- PhD, Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2007
- MS, Biochemistry, RML Avadh University, Faizabad, UP, India, 2000
- BA, Zoology, Chemistry and Botany, VB Singh Purvanchal University, Jaunpur, UP, India, 1996
- Society of Neuroscience India
- American Heart Association
Lal, H, Verma, SK, Golden, HB, Foster, DM, Holt, AM and Dostal, DE. Molecular Signaling Mechanisms of Myocardial Stretch: Implications for Heart Disease Chapter 3 (55-81). In Mechanosensitivity in Cells and Tissues: Mechanosensitivity of the Heart, Kamkin, Andre; Kiseleva, Irina (Eds), Springer 2010.
Golden, HB, Verma, SK, Lal, H, Foster, DM, Ribeiro, M, Mukhopadhyay, S and Dostal, DE. Mechanical Regulation of Stress-Activated MAP Kinases, Chapter 9 (pp. 1-29). In: The Cardiac Fibroblast, Editor: Neil A. Turner, Research Signpost, Kerala, India, 2011.
Verma, SK, Krishnamurthy, P and Kishore, R: Transverse aortic constriction: a model to study heart failure in small animals. Chapter 20 (pp. 164-169). Manual of Research Techniques in Cardiovascular Medicine. Edited by Hossein Ardehali, Douglas Losordo and Roberto Bolli. Wiley-Blackwell publisher (2014).
Krishnamurthy, P, Verma, SK and Kishore, R. Murine bone marrow transplantation. Chapter 17 (pp. 146-148). Manual of Research Techniques in Cardiovascular Medicine. Edited by Hossein Ardehali, Douglas Losordo, and Roberto Bolli. Wiley-Blach11ell publisher (2014).