In This Section

Lee Peng, MD, PhD

Professor, Clinical Medicine
Director, Hepatology Fellowship Program

Contact Information

Contact Information

Phone

215-707-9900

About Me

Clinical Interests

Hepatology
Liver disease
Cirrhosis
Viral hepatitis
Metabolic liver disease
Autoimmune hepatitis
Primary biliary cirrhosis (PBC)
Primary sclerosing cholangitis (PSC)
Hemochromatosis
Wilson's disease
Alcoholic liver disease
Fatty liver disease/nonalcoholic steatohepatitis (NASH)
Ascites
Varices
Hepatic encephalopathy
Endoscopy - esophagogastroduodenoscopy (EGD) and colonoscopy
Chemistry
Chemical biology

Education, Training & Credentials

Educational Background

Fellowship, Gastroenterology, Massachusetts General Hospital, Boston, MA, 2007
Residency, Internal Medicine, Massachusetts General Hospital, Boston, MA, 2003
MD, Harvard Medical School, Cambridge, MA, 2001
PhD, Chemistry, Harvard University, Cambridge, MA, 1999
AB, Chemistry, Harvard University, Cambridge, MA, 1991

Certifications

Internal Medicine
Gastroenterology

Memberships

American Association of Study of Liver Diseases
American Gastroenterology Association
American Medical Association

Publications

Publications

Lin W, Zhu C, Hong J, Zhao L, Jilg N, Fusco DN, Schaefer EA, Brisac C, Liu X, Peng, LF, Xu Q, Chung RT, The spliceosome factor SART1 exerts its anti-HCV action through mRNA splicing. Journal of Hepatology, 2014, doi: http://dx.doi.org/10.1016/j.jhep.2014.11.038

Jilg N, Lin W, Hong J, Schaefer EA, Wolski D, Meixong J, Goto K, Brisac C, Chusri P, Fusco DN, Chevaliez S, Luther J, Kumthip K, Urban TJ, Peng LF, Lauer GM, Chung RT. Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus. Hepatology, 2014, 59(4): 1250-1261.

Goto K, Lin W, Zhang L, Jilg N, Shao RX, Schaefer EA, Zhao H, Fusco DN, Peng LF, Kato N, Chung RT. The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling. J. Hepatol, 2013, 59(5):942-8... Expand

Fusco DN, Brisac C, John SP, Huang YW, Chin CR, Xie T, Zhao H, Zhang L, Chevalier S, Wambua D, Lin W, Peng L, Chung RT, Brass AL. A Genetic Screen Identifies Interferon-α Effector Genes Required to Suppress Hepatitis C Virus Replication. Gastroenterology, 2013, 144(7): 1438-49.

Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models. Cell Stem Cell, 2013, 12(2):238-51.

Shao RX, Zhang L, Hong Z, Goto K, Cheng D, Chen WC, Jilg N, Kumthip K, Fusco DN, Peng LF, Chung RT. SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication. Antiviral Res., 2013, 97(2):101-7.

Kumthip K, Chusri P, Jilg N, Zhao L, Fusco DN, Zhao H, Goto K, Cheng D, Schaefer EA, Zhang L, Pantip C, Thongsawat S, O'Brien A, Peng LF, Maneekarn N, Chung RT, Lin W. Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling. J. Virol., 2012, 86(16):8581-91.

Rodgers M.A.; Villareal, V.A.; Schaefer, E.A.; Peng, L.F.; Corey, K.E.; Chung, R.T.; Yang, P.L. Lipid Metabolite Profiling Identifies Desmosterol Metabolism as a New Antiviral Target for Hepatitis C Virus. J Am Chem Soc., 2012, 134(16): 6896-9.

Zhao, H.; Lin, W.; K. Kumthip, K; Cheng, D.; Fusco, D.N.; Hofmann, O.; Jilg, N.; Tai, A.W.; Goto, K. Zhang, L.; Hide, W.; Jang, J.Y.; Peng, L.F.; Chung, R.T. A functional genomic screen reveals novel host genes that mediate interferon-alpha’s effects against hepatitis C virus. J Hepatol., 2012, 56 (2): 326-333.

Peng, Lee F.; Schaefer, Esperance; Maloof, Nicole; Skaff, Andrew; Berical, Andrew; Belon, Craig A.; Heck, Julie A.; Lin, Wenyu; Frick, David N.; Allen, Todd M.; Miziorko, Henry; Schreiber, Stuart L.; Chung, Raymond T. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits HMG-CoA synthase. Journal of Infectious Disease, 2011, 204: 609-616.

Lin, W.; Wu, G.; Li, S.; Weinberg, E.M.; Kumthip, K.; Peng, Lee F.; Méndez-Navarro, J.; Chen, W.C.; Jilg, N.; Zhao, H.; Goto, K.; Zhang, L.; Brockman, M.A.; Schuppan, D.; Chung, R.T. HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB. J. Biol. Chem., 2011, 286(4):2665-74.

Jang J.Y.; Shao, R.X.; Lin, W.; Weinberg, E.; Chung, W.J.; Tsai, W.L.; Zhao, H.; Goto, K.; Zhang, L.; Mendez-Navarro, J.; Jilg, N.; Peng, Lee F., Brockman, M.A.; Chung, R.T. HIV infection increases HCV-induced hepatocyte apoptosis. J. Hepatology, 2011, 54(4): 612-620.

Zhang, L.; Jilg, N.; Shao, R.X.; Lin, W.; Fusco, D. N.; Zhao, H.; Goto, K.; Peng, Lee F.; Chen, W.-C.; Chung, R. T. IL28B inhibits Hepatitis C virus replication through the JAK-STAT pathway. J. Hepatology, 2011, 55(2): 289-298.

Shao, R. X.; Zhang, L.; Peng, L. F.; Sun, E.; Chung, W. J.; Jang, J. Y.; Tsai, W.L.; Hyppolite, G.; Chung, R .T. Suppressor of cytokine signaling 3 suppresses hepatitis C virus replication in an mTOR-dependent manner. J. Virology, 2010, 84(12): 6060-6069.

Lin, Wenyu; Tsai, W. L.; Shao, R. X.; Wu, G.; Peng, Lee F.; Barlow, L. L.; Chung, W. J.; Zhang, L.; Zhao, H.; Jang, J. Y.; Chung, R.T. Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner. Gastroenterology, 2010, 138(7):2059-2518.

Peng, Lee F.;* Stanton, Benjamin Z.;* Maloof, Nicole; Nakai, Kazuo; Wang, Xiang; Chen, James K.; Schreiber, Stuart L. Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. Bio-organic and Medicinal Chemistry Letters, 2009, 19:6319-25. * L.F.P. and B.Z.S. contributed equally to this project. L.F.P. was corresponding author on this publication.

Chen, Shuibing; Borowiak, Malgorzata; Fox, Julia L.; Maehr, Rene; Osafune, Kenji; Davidow, Lance; Lam, Kelvin; Peng, Lee F.; Schreiber, Stuart L.; Rubin, Lee L.; Melton, Douglas. A small molecule that directs differentiation of human embryonic stem cells into the pancreatic lineage. 2009. Nature Chemical Biology, 5: 258-265.

Stanton, Benjamin Z.;* Peng, Lee F.;* Maloof, Nicole; Nakai, Kazuo; Wang, Xiang; Duffner, Jay L.; Taveras, Kennedy; Hyman, Joel M.; Lee, Sam W.; Koehler, Angela N.; Chen, James K.; Fox, Julia L.; Mandinova, Anna; Schreiber, Stuart L. Discovery and characterization of a small molecule that inhibits Sonic Hedgehog (Shh) activity. Nature Chemical Biology, 2009, 5: 154-156. * B.Z.S. and L.F.P. contributed equally to this project. L.F.P. was corresponding author on this publication.

Tai, Andrew W.; Benita, Yair; Peng, Lee F.; Kim, Sun-Suk; Sakamoto, Naoya; Xavier, Ramnik J.; Chung, Raymond T. A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host and Microbe, 2009, 5: 298-307.

Lin, W.; Weinberg, E. M.; Tai, A. W.; Peng, L. F.; Brockman, M. A.; Kim, K. A.; Kim, S.S.; Borges, C. B.; Shao, R. X.; Chung, R. T. HIV increases HCV replication in a TGF-beta1-dependent manner. Gastroenterology, 2008, 134(3), 803-811.

Peng, Lee F.; * Kim, Sun Suk;* Matchacheep, Sirinya; Lin, Wenyu; Choe, Won-Hyeok; Sakamoto, Naoya; Schreiber, Stuart L.; Chung, Raymond T. Identification of Novel Epoxide Inhibitors of HCV Replication Via High-Throughput Screening.

Antimicrobial Agents and Chemotherapy 2007, 51: 3756-3759. * L.F.P. and S.S.K. contributed equally to this project.

Kim, Sun Suk; * Peng, Lee F.; * Lin, Wenyu; Choe, Won-Hyeok; Sakamoto, Naoya; Schreiber, Stuart L.; Chung, Raymond T. A Cell-Based, High-Throughput Screen for Small Molecule Regulators of HCV Replication. Gastroenterology, 2007, 132(1), 311-320.* S.S.K. and L.F.P. contributed equally to this project.

Shi, Y., Peng, L. F., Kishi, Y. Enantioselective Total Synthesis of Fumonisin B2. J. Org. Chem., 1997, 62, 5666. Collapse