Jian Huang, MD, PhD
We are very interested in studying the signaling pathways that drive normal hematopoiesis and hematopoietic malignancies. Specifically, our research focuses on three main topics: 1. Understanding the role of Wnt signaling in the regulation of Hematopoietic Stem Cells (HSCs) self-renewal, and the contribution of Wnt signaling to leukemogenesis; 2. Identifying new factors and signaling pathways involved in regulating HSC self-renewal using the ex vivo culture system; 3. Investigating the roles of epigenetic regulation in HSCs and leukemia stem cells (LSCs). The knowledge gained from these studies will provide new insights into the mechanisms of the regulation of HSCs self-renewal and differentiation, as well as the molecular and cellular biology of leukemia stem cells. It will be valuable for the diagnosis and prevention of hematopoietic diseases and the development of innovative therapeutics for many hematopoietic disorders.