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Bin Xu, PhD

Assistant Professor, Cardiovascular Research Center

Bin Xu
Contact Information

Contact Information

About Me

Research Interests

We are interested in cellular and molecular mechanisms involved in cardiac failure/hypertrophy/fibrosis, and hypertension. By using genetically modified mouse models, we are discovering novel signal pathways and helping to develop new drugs and strategies to protect heart against genetic defects and diseases.

Education, Training & Credentials

Educational Background

  • Fellowship, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA
  • Fellowship, Hemostasis and Thrombosis, NIH Training Program
  • Fellowship, Cardiovascular Biology and Medicine, NIH Training Program
  • PhD, Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
  • BS, Microbiology, Sichuan University, Chengdu, China

Recent Publications

Bin Xu, Jennifer Hu, Anbin Mu, Peter Z. Xu, Kenneth B. Margulies, Lawrence H. Young, Daniel L. Dries. Effect of Corin Genotype on Cardiac Natriuretic Peptide Processing in the Intact Heart under Cardiac Pressure-Overload Conditions (in revision).

Bin Xu, Ping Qu, Walter Koch, Steven Houser, Erhe Gao, John Dodd, Carl Spana,  Daniel L. Dries. Cardiomyocyte-restricted deletion of Corin promotes pathological hypertrophy in response to pressure-overload but is rescued by PL3994, a selective guanylate-cyclase type A receptor peptide agonist (in revision).

Rebecca Lee*, Bin Xu*, J. Eduardo Rame, Leanne Felkin, Paul Barton, Daniel L. Dries. Regulated Inositol-Requiring Protein 1-Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure. Journal of the American Heart Association; Dec2014, Vol. 3 Issue 6, p1-15. (*RL and BX* are co-first authors.)

Dake Qi, Kwame Atsina, Lintao Qu, Xiaoyue Hu, Xiaohong Wu, Bin Xu, Marta Piecychna, Lin Leng, Günter Fingerle-Rowson, Richard Bucala, Lawrence Young. The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury. Journal of Clinical Investigation. Aug 2014, Vol. 124 Issue 8, p3540, 11 p.