In This Section

Biao Dong, PhD

Assistant Professor, Sol Sherry Thrombosis Research Center

Biao Dong
Contact Information

Contact Information

Phone

215-707-7774

Fax

215-707-2783

Email

dongb@temple.edu
About Me

Research Interests

My general research interest is gene therapy mediated by viral vectors including adeno-associated virus (AAV), adenovirus, lentivirus, etc. Currently, my research is focused on AAV gene therapy for Hemophilia A, which includes two aspects: 1) producing AAV vectors with high infectious titer and ease of scaling-up; 2) engineering Factor VIII with higher activity and longer half-life.

Education, Training & Credentials

Educational Background

  • PhD, Molecular Biology, Chinese University of Hong Kong, 2004
  • MS, Microbiology, Nankai University, 1999
  • BS, Huazhong Agricultural University, 1992
Publications

PubMed Publications

25596744. Chow HY, Dong B, Duron SG, Campbell DA, Ong CC, Hoeflich KP, Chang LS, Welling DB, Yang ZJ, Chernoff J, Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget 6:4(1981-94)2015 Feb 10

25093498. Wang Q, Dong B, Firrman J, Roberts S, Moore AR, Cao W, Diao Y, Kapranov P, Xu R, Xiao W, Efficient production of dual recombinant adeno-associated viral vectors for factor VIII delivery. Hum Gene Ther Methods 25:4(261-8)2014 Aug

24498275. Dong B, Duan X, Chow HY, Chen L, Lu H, Wu W, Hauck B, Wright F, Kapranov P, Xiao W, Proteomics analysis of co-purifying cellular proteins associated with rAAV vectors. PLoS One 9:2(e86453)2014

23677609. Dong B, Moore AR, Dai J, Roberts S, Chu K, Kapranov P, Moss B, Xiao W, A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy. Nucleic Acids Res 41:13(6609-17)2013 Jul

25401041. Mao J, Xi X, Kapranov P, Dong B, Firrman J, Xu R, Xiao W, In vitro and In vivo Model Systems for Hemophilia A Gene Therapy. J Genet Syndr Gene Ther Suppl 1:()2013 Jan 17

23565342. Roberts SA, Dong B, Firrman JA, Moore AR, Sang N, Xiao W, Engineering Factor Viii for Hemophilia Gene Therapy. J Genet Syndr Gene Ther 1:()2011 Dec 21

21875357. Kapranov P, Chen L, Dederich D, Dong B, He J, Steinmann KE, Moore AR, Thompson JF, Milos PM, Xiao W, Native molecular state of adeno-associated viral vectors revealed by single-molecule sequencing. Hum Gene Ther 23:1(46-55)2012 Jan

19904236. Dong B, Nakai H, Xiao W, Characterization of genome integrity for oversized recombinant AAV vector. Mol Ther 18:1(87-92)2010 Jan

18471027. Valencia CA, Cotten SW, Dong B, Liu R, mRNA-display-based selections for proteins with desired functions: a protease-substrate case study. Biotechnol Prog 24:3(561-9)2008 May-Jun

18452715. Dong B, Liu R, Characterization of endogenous and recombinant human calpain-10. Biochimie 90:9(1362-71)2008 Sep

17854888. Shen X, Valencia CA, Gao W, Cotten SW, Dong B, Huang BC, Liu R, Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium 43:5(444-56)2008 May

17728405. Ju W, Valencia CA, Pang H, Ke Y, Gao W, Dong B, Liu R, Proteome-wide identification of family member-specific natural substrate repertoire of caspases. Proc Natl Acad Sci U S A 104:36(14294-9)2007 Sep 4

17580302. Dong B, Valencia CA, Liu R, Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1. J Biol Chem 282:34(25131-40)2007 Aug 24

15840729. Shen X, Valencia CA, Szostak JW, Dong B, Liu R, Scanning the human proteome for calmodulin-binding proteins. Proc Natl Acad Sci U S A 102:17(5969-74)2005 Apr 26