Andrew Gibb, PhD
Instructor (Research), Cardiovascular Research Center
- Contact Information
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- About Me
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Clinical Interests
Many disease states are directly linked to alterations in metabolism, resulting in and directly contributing to disease progression. Specifically, remodeling of cellular metabolism and metabolic dysfunction is associated with cardiac hypertrophy, cardiac fibrosis, and ultimately heart failure, which our research has directly shown a metabo-centric causative role. My long-term research interests are aimed at developing a comprehensive understanding of the metabolic underpinnings that promote cardiovascular health and contribute to disease progression.
Currently, I am investigating the potential for a cardiomyocyte-to-fibroblast metabolic crosstalk mediating tissue fibrosis in heart failure. I am also investigating the intracellular metabolite transport between the mitochondria and nucleus to dissect the metabolic regulation of epigenetic remodeling necessary for responses to stress stimuli in the heart. Lastly, utilizing unbiased systems biology approaches (e.g. ATAC-seq, RNA-seq, Metabolomics), I am investigating numerous novel transcription factors, genes, and metabolic pathways to identify novel targets and regulatory mechanisms mediating HF pathophysiology.
The overall goal of my research is to establish a highly collaborative group conducting research in mitochondrial, metabolic, and cardiovascular biology to address impactful unanswered questions to advance scientific knowledge, benefiting human health with novel therapeutic strategies towards cardiovascular disease.
- Education, Training & Credentials
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Educational Background
- PhD, University of Louisville, Louisville, KY
Memberships
- Basic Science Council, American Heart Association
- International Society for Heart Research
- American Physiological Society
- Publications
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Digital Bibliography
https://www.ncbi.nlm.nih.gov/myncbi/1zaQ55Bhiyh5x/bibliography/public/
Additional Publications
- Related Links